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    Smim1 small integral membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 68859, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Smim1provided by MGI
    Official Full Name
    small integral membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1916109
    See related
    Ensembl:ENSMUSG00000078350 AllianceGenome:MGI:1916109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610011H04Rik; 1190007F08Rik; 2700009I11Rik
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be located in cell surface and plasma membrane. Orthologous to human SMIM1 (small integral membrane protein 1 (Vel blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 46.8), liver E14.5 (RPKM 44.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smim1 in Genome Data Viewer
    Location:
    4 E2; 4 83.79 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154104927..154110550, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154020470..154026085, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor, beta subunit Neighboring gene centrosomal protein 104 Neighboring gene predicted gene, 31566 Neighboring gene leucine rich repeat containing 47 Neighboring gene coiled-coil domain containing 27 Neighboring gene transformation related protein 73 Neighboring gene STARR-seq mESC enhancer starr_12227 Neighboring gene STARR-seq mESC enhancer starr_12228 Neighboring gene predicted gene, 26036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163721.1 → NP_001157193.1  small integral membrane protein 1

      See identical proteins and their annotated locations for NP_001157193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004513, BC080682
      Consensus CDS
      CCDS59664.1
      UniProtKB/Swiss-Prot
      P0C8K7
      Related
      ENSMUSP00000138605.2, ENSMUST00000146054.8
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 77
      DUF4731; Domain of unknown function (DUF4731)

    2. NM_001163722.1 → NP_001157194.1  small integral membrane protein 1

      See identical proteins and their annotated locations for NP_001157194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC080682, BC172044
      Consensus CDS
      CCDS59664.1
      UniProtKB/Swiss-Prot
      P0C8K7
      Related
      ENSMUSP00000138324.2, ENSMUST00000125533.9
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 77
      DUF4731; Domain of unknown function (DUF4731)

    3. NM_001357248.1 → NP_001344177.1  small integral membrane protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004513, BC080682, W57265
      Consensus CDS
      CCDS59664.1
      UniProtKB/Swiss-Prot
      P0C8K7
      Related
      ENSMUSP00000138471.2, ENSMUST00000132541.8
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 77
      DUF4731; Domain of unknown function (DUF4731)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154104927..154110550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539148.5 → XP_006539211.1  small integral membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539211.1

      UniProtKB/Swiss-Prot
      P0C8K7
      Related
      ENSMUSP00000138448.2, ENSMUST00000145527.8
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 77
      DUF4731; Domain of unknown function (DUF4731)

    2. XM_017320379.3 → XP_017175868.1  small integral membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P0C8K7
      Related
      ENSMUSP00000138675.2, ENSMUST00000130175.8
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 77
      DUF4731; Domain of unknown function (DUF4731)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033144.2: Suppressed sequence

      Description
      NM_001033144.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C8K7.1 GenPept UniProtKB/Swiss-Prot:P0C8K7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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