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    Tprg1l transformation related protein 63 regulated 1 like [ Mus musculus (house mouse) ]

    Gene ID: 67808, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tprg1lprovided by MGI
    Official Full Name
    transformation related protein 63 regulated 1 likeprovided by MGI
    Primary source
    MGI:MGI:1915058
    See related
    Ensembl:ENSMUSG00000029030 AllianceGenome:MGI:1915058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tprgl; mover; Svap30; 1200015A19Rik
    Summary
    Enables calmodulin binding activity and identical protein binding activity. Acts upstream of or within calcineurin-NFAT signaling cascade; negative regulation of synaptic transmission; and synaptic vesicle docking. Located in presynapse. Is expressed in several structures, including gut; hemolymphoid system gland; male reproductive gland or organ; nervous system; and nose. Orthologous to human TPRG1L (tumor protein p63 regulated 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 110.0), lung adult (RPKM 103.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tprg1l in Genome Data Viewer
    Location:
    4 E2; 4 83.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154241942..154246763, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154157485..154162306, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transformation related protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4737 Neighboring gene predicted gene, 26036 Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene STARR-seq mESC enhancer starr_12229 Neighboring gene multiple EGF-like-domains 6 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 16 Neighboring gene predicted gene, 52687

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of a subset of release-ready vesicles by the presynaptic protein Mover. Pofantis E, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33431696, Free PMC Article
    2. Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. Burré J, et al. Electrophoresis, 2006 Sep. PMID 16944461
    3. Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Burré J, et al. Proteomics, 2006 Dec. PMID 17080482
    4. Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. Kremer T, et al. FEBS Lett, 2007 Oct 2. PMID 17869247
    5. The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting. Akula AK, et al. Front Mol Neurosci, 2019. PMID 31787876, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of a subset of release-ready vesicles by the presynaptic protein Mover.
      Title: Regulation of a subset of release-ready vesicles by the presynaptic protein Mover.
    2. Tprgl is a ubiquitously expressed gene located upstream of the p73 gene. Its encoded protein displays 44% amino acid identity with the protein encoded by Tprg, a p63 target gene that is located upstream of the p63 gene.
      Title: Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63.
    3. mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals
      Title: Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in calyx of Held ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein p63-regulated gene 1-like protein
    Names
    mossy-fiber terminal-associated vertebrate-specific presynaptic protein
    synaptic vesicle associated protein of 30 kD
    transformation related protein 63 regulated like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026388.2 → NP_080664.1  tumor protein p63-regulated gene 1-like protein

      See identical proteins and their annotated locations for NP_080664.1

      Status: VALIDATED

      Source sequence(s)
      AI840915, AK004324, AK004777, BY739996
      Consensus CDS
      CCDS19011.1
      UniProtKB/Swiss-Prot
      B1AX99, Q8BTC6, Q9DBS2
      Related
      ENSMUSP00000030896.9, ENSMUST00000030896.15
      Conserved Domains (1) summary
      pfam12456
      Location:61 → 162
      hSac2; Inositol phosphatase

    RNA

    1. NR_151647.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI840915, AK004324, AK004777, AL806525, BY739996

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154241942..154246763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539129.4 → XP_006539192.3  tumor protein p63-regulated gene 1-like protein isoform X1

      Conserved Domains (2) summary
      pfam12456
      Location:174 → 264
      hSac2; Inositol phosphatase
      cl02324
      Location:93 → 197
      DUF721; Protein of unknown function (DUF721)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBS2.1 GenPept UniProtKB/Swiss-Prot:Q9DBS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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