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    Ltb4r2 leukotriene B4 receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 57260, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ltb4r2provided by MGI
    Official Full Name
    leukotriene B4 receptor 2provided by MGI
    Primary source
    MGI:MGI:1888501
    See related
    Ensembl:ENSMUSG00000040432 AllianceGenome:MGI:1888501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BLT2; LTB4-R2; LTB4-R 2; LTB4-R-2; 5830462O07Rik
    Summary
    Enables leukotriene B4 receptor activity. Acts upstream of or within keratinocyte migration and signal transduction. Located in membrane. Orthologous to human LTB4R2 (leukotriene B4 receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 18.1), small intestine adult (RPKM 13.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ltb4r2 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55995379..56001523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55757922..55764066)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 1 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene STARR-seq mESC enhancer starr_36778 Neighboring gene leukotriene B4 receptor 1 Neighboring gene adenylate cyclase 4 Neighboring gene predicted gene, 32092

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice. Hoyer FF, et al. Mol Cell Biochem, 2012 Jan. PMID 21755457
    2. BLT2 Is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines. Cho KJ, et al. J Immunol, 2010 Nov 15. PMID 20952677
    3. Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis. Park D, et al. Mol Cells, 2021 Dec 31. PMID 34887363, Free PMC Article
    4. Leukotriene B(4) Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. Matsumoto Y, et al. J Pharmacol Exp Ther, 2020 Apr. PMID 31941716
    5. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B(4) receptor 2. Iwamoto S, et al. Sci Rep, 2017 Oct 16. PMID 29038497, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation.
      Title: Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation.
    2. Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
      Title: Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
    3. Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis.
      Title: Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis.
    4. Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
      Title: Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
    5. Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
      Title: Leukotriene B(4) receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
    6. Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
      Title: Leukotriene B(4) Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
    7. FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages
      Title: Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling.
    8. findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
      Title: Lipopolysaccharide/TLR4 Stimulates IL-13 Production through a MyD88-BLT2-Linked Cascade in Mast Cells, Potentially Contributing to the Allergic Response.
    9. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
      Title: Macrophage LTB(4) drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2.
    10. BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma.
      Title: Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123942, MGC123943

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene B4 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene B4 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within keratinocyte migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leukotriene B4 receptor 2
    Names
    leukotriene B4 receptor BLT2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020490.3 → NP_065236.1  leukotriene B4 receptor 2

      See identical proteins and their annotated locations for NP_065236.1

      Status: VALIDATED

      Source sequence(s)
      AC098877
      Consensus CDS
      CCDS27128.1
      UniProtKB/Swiss-Prot
      Q3KP98, Q9JJL9
      Related
      ENSMUSP00000048358.5, ENSMUST00000044554.5
      Conserved Domains (2) summary
      cd14964
      Location:23 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21 → 300
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55995379..56001523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519323.3 → XP_006519386.1  leukotriene B4 receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_006519386.1

      Conserved Domains (2) summary
      cd14964
      Location:34 → 60
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006519326.3 → XP_006519389.1  leukotriene B4 receptor 2 isoform X2

      See identical proteins and their annotated locations for XP_006519389.1

      UniProtKB/Swiss-Prot
      Q3KP98, Q9JJL9
      Conserved Domains (2) summary
      cd14964
      Location:23 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21 → 300
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_036158769.1 → XP_036014662.1  leukotriene B4 receptor 2 isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:34 → 60
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJL9.1 GenPept UniProtKB/Swiss-Prot:Q9JJL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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