Ecm2 extracellular matrix protein 2, female organ and adipocyte specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ecm2provided by MGI
Official Full Name: extracellular matrix protein 2, female organ and adipocyte specificprovided by MGI
Primary source: MGI:MGI:3039578
See related: Ensembl:ENSMUSG00000043631 AllianceGenome:MGI:3039578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: tenonectin; 9030618O22Rik
Summary: Enables collagen V binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in interstitial matrix. Is expressed in several structures, including brain; heart valve; sensory organ; tendon; and ventricular layer. Orthologous to human ECM2 (extracellular matrix protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in bladder adult (RPKM 4.5), heart adult (RPKM 3.2) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.29 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49658259..49686267)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49504810..49532789)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen V binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen V binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: extracellular matrix protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012324.4 → NP_001012324.1 extracellular matrix protein 2 precursor

See identical proteins and their annotated locations for NP_001012324.1

Status: VALIDATED

Source sequence(s)

AC123954

Consensus CDS

CCDS26502.1

UniProtKB/Swiss-Prot

Q5FW85

Related

ENSMUSP00000060402.8, ENSMUST00000051504.8

Conserved Domains (5) summary

cd00116
Location:314 → 591

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:316 → 339

LRR_RI; leucine-rich repeat [structural motif]

pfam00093
Location:98 → 152

VWC; von Willebrand factor type C domain

pfam12799
Location:580 → 619

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:314 → 376

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

49658259..49686267

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158082.1 → XP_036013975.1 extracellular matrix protein 2 isoform X1

Conserved Domains (3) summary

sd00031
Location:296 → 315

LRR_1; leucine-rich repeat [structural motif]

pfam00093
Location:98 → 152

VWC; von Willebrand factor type C domain

pfam13855
Location:314 → 360

LRR_8; Leucine rich repeat