Ddx17 DEAD box helicase 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx17provided by MGI
Official Full Name: DEAD box helicase 17provided by MGI
Primary source: MGI:MGI:1914290
See related: Ensembl:ENSMUSG00000055065 AllianceGenome:MGI:1914290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p72; Gm926; 2610007K22Rik; A430025E01Rik
Summary: This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in limb E14.5 (RPKM 143.7), CNS E14 (RPKM 143.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.77 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79411897..79430976, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79527696..79546764, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure.
Title: DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure.
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
Title: DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
Mechanistic studies reveal that MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17. The identification of MeXis as a lncRNA modulator of LXR-dependent gene expression expands understanding of the mechanisms underlying cell type-selective actions of nuclear receptors in physiology and disease.
Title: Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
Data show that p72/DDX17 specifically interacts with the miR-132 loop sequence and influences the relative ratio of the mature mice miR-212/132 miRNAs.
Title: The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132.
Downregulation of DDX5 and DDX17 protein expression during myogenesis and epithelial-to-mesenchymal transdifferentiation contributes to the switching of splicing programs during these processes.
Title: RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.
Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor.
Title: Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237349

NoName (e-PCR)
- UniSTS:237353

AI173274 (e-PCR)
- UniSTS:180784

RH28487 (e-PCR)
- UniSTS:88928

D15H22S314E (e-PCR), detects polymorphism
- UniSTS:88928

RH135838 (e-PCR)
- UniSTS:209836

Ddx17 (e-PCR), detects polymorphism
- UniSTS:527308

AW743179 (e-PCR)
- UniSTS:209109

C80929 (e-PCR)
- UniSTS:160470

RH126991 (e-PCR)
- UniSTS:209111

AA819656 (e-PCR)
- UniSTS:243451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX17

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 17; DEAD box protein 17

NP_001035277.1

EC 3.6.4.13

NP_690019.2

EC 3.6.4.13

NP_951061.1

EC 3.6.4.13

NP_951062.1

EC 3.6.4.13

XP_030104566.1

EC 3.6.4.13

XP_036015440.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040187.1 → NP_001035277.1 probable ATP-dependent RNA helicase DDX17 isoform 4

See identical proteins and their annotated locations for NP_001035277.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 4).

Source sequence(s)

BC096036, CX220180

Consensus CDS

CCDS88805.1

UniProtKB/Swiss-Prot

Q501J6, Q6P5G1, Q8BIN2

Related

ENSMUSP00000155307.2, ENSMUST00000229877.2

Conserved Domains (1) summary

cl26939
Location:32 → 500

DEXDc; DEAD-like helicases superfamily
NM_152806.3 → NP_690019.2 probable ATP-dependent RNA helicase DDX17 isoform 3

See identical proteins and their annotated locations for NP_690019.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 3) is much shorter with a different N-terminus when compared to isoform 1.

Source sequence(s)

BC038378, CD350507, CX220180

UniProtKB/TrEMBL

Q3U6Y5, Q8K392

Conserved Domains (1) summary

cd00079
Location:22 → 60

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
NM_199079.2 → NP_951061.1 probable ATP-dependent RNA helicase DDX17 isoform 2

See identical proteins and their annotated locations for NP_951061.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two coding region segments, uses a different splice site in the 3' coding region, and contains a distinct 3' UTR, compared to transcript variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC117806

Consensus CDS

CCDS88804.1

UniProtKB/TrEMBL

Q3TU25

Related

ENSMUSP00000155737.2, ENSMUST00000229431.2

Conserved Domains (1) summary

cl26939
Location:32 → 403

DEXDc; DEAD-like helicases superfamily
NM_199080.2 → NP_951062.1 probable ATP-dependent RNA helicase DDX17 isoform 1

See identical proteins and their annotated locations for NP_951062.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform 1).

Source sequence(s)

AK152831, BC038378, BC096036, CX220180

Consensus CDS

CCDS27643.1

UniProtKB/TrEMBL

Q3U741

Related

ENSMUSP00000055535.7, ENSMUST00000054014.9

Conserved Domains (1) summary

cl26939
Location:32 → 502

DEXDc; DEAD-like helicases superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79411897..79430976 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159547.1 → XP_036015440.1 probable ATP-dependent RNA helicase DDX17 isoform X2

Conserved Domains (1) summary

PTZ00110
Location:1 → 226

PTZ00110; helicase; Provisional
XM_030248706.1 → XP_030104566.1 probable ATP-dependent RNA helicase DDX17 isoform X1

Conserved Domains (1) summary

PTZ00110
Location:1 → 228

PTZ00110; helicase; Provisional