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    Slc30a7 solute carrier family 30 (zinc transporter), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 66500, updated on 2-Nov-2024

    Summary

    Official Symbol
    Slc30a7provided by MGI
    Official Full Name
    solute carrier family 30 (zinc transporter), member 7provided by MGI
    Primary source
    MGI:MGI:1913750
    See related
    Ensembl:ENSMUSG00000054414 AllianceGenome:MGI:1913750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZnT7; ZnT-7; Zntl2; 1810059J10Rik; 2610034N15Rik; 4833428C12Rik
    Summary
    Enables zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis and zinc ion import into Golgi lumen. Acts upstream of or within zinc ion transport. Located in Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including nervous system and urinary system. Orthologous to human SLC30A7 (solute carrier family 30 member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.4), limb E14.5 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc30a7 in Genome Data Viewer
    Location:
    3 G1; 3 50.16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (115732622..115801079, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (115938973..116007414, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930005H10 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:115591074-115591257 Neighboring gene diphthamide biosynthesis 5 Neighboring gene predicted gene, 54180 Neighboring gene E74-like factor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4581 Neighboring gene microRNA 669n Neighboring gene STARR-positive B cell enhancer ABC_E3462 Neighboring gene exostosin-like glycosyltransferase 2 Neighboring gene predicted gene, 26344

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IC
    Inferred by Curator
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion import into Golgi lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion import into Golgi lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion import into Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within zinc ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cis cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cis cisterna membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc transporter 7
    Names
    solute carrier family 30 member 7
    znt-like transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023214.7NP_075703.1  zinc transporter 7

      See identical proteins and their annotated locations for NP_075703.1

      Status: VALIDATED

      Source sequence(s)
      AC108909, AC131113, AK075802
      Consensus CDS
      CCDS17783.1
      UniProtKB/Swiss-Prot
      Q80Y27, Q9JKN1
      Related
      ENSMUSP00000065254.4, ENSMUST00000067485.4
      Conserved Domains (2) summary
      COG1230
      Location:31376
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:48296
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      115732622..115801079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163227.1XP_036019120.1  zinc transporter 7 isoform X1

      Conserved Domains (1) summary
      COG1230
      Location:31284
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    2. XM_011240194.2XP_011238496.1  zinc transporter 7 isoform X2

      Conserved Domains (1) summary
      COG1230
      Location:31159
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]