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    Zfp553 zinc finger protein 553 [ Mus musculus (house mouse) ]

    Gene ID: 233887, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp553provided by MGI
    Official Full Name
    zinc finger protein 553provided by MGI
    Primary source
    MGI:MGI:2384725
    See related
    Ensembl:ENSMUSG00000045598 AllianceGenome:MGI:2384725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf48; 2600009K23Rik; C330013F15Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human ZNF48 (zinc finger protein 48). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 13.4), CNS E11.5 (RPKM 12.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp553 in Genome Data Viewer
    Location:
    7 F3; 7 69.4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126832233..126837369)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127233061..127238197)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene septin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134404258-134404441 Neighboring gene dCTP pyrophosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp553 Is Essential for Maintenance and Acquisition of Pluripotency. Yu S, et al. Stem Cells Dev, 2016 Jan 1. PMID 26423361
    2. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291
    3. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31231

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 48

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360912.1 → NP_001347841.1  zinc finger protein 48

      Status: VALIDATED

      Source sequence(s)
      AC133494, AK146581
      Consensus CDS
      CCDS21860.1
      UniProtKB/Swiss-Prot
      Q3UFP3, Q3US17, Q8R0V0, Q921H7
      Related
      ENSMUSP00000060967.7, ENSMUST00000056232.7
      Conserved Domains (3) summary
      COG5048
      Location:161 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:85 → 105
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:97 → 120
      zf-H2C2_2; Zinc-finger double domain

    2. NM_146201.2 → NP_666313.1  zinc finger protein 48

      See identical proteins and their annotated locations for NP_666313.1

      Status: VALIDATED

      Source sequence(s)
      AC133494, AK049208
      Consensus CDS
      CCDS21860.1
      UniProtKB/Swiss-Prot
      Q3UFP3, Q3US17, Q8R0V0, Q921H7
      Related
      ENSMUSP00000101919.4, ENSMUST00000106312.4
      Conserved Domains (3) summary
      COG5048
      Location:161 → 572
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:85 → 105
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:97 → 120
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126832233..126837369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3US17.2 GenPept UniProtKB/Swiss-Prot:Q3US17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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