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    Rad51ap1 RAD51 associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19362, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rad51ap1provided by MGI
    Official Full Name
    RAD51 associated protein 1provided by MGI
    Primary source
    MGI:MGI:1098224
    See related
    Ensembl:ENSMUSG00000030346 AllianceGenome:MGI:1098224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAB22; 2510006L10Rik
    Summary
    Predicted to enable nucleic acid binding activity. Acts upstream of or within DNA recombination. Located in chromosome and nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; gut; reproductive system; and trachea. Orthologous to human RAD51AP1 (RAD51 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 17.5), liver E14.5 (RPKM 14.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rad51ap1 in Genome Data Viewer
    Location:
    6 F3; 6 61.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126900378..126916664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126923415..126939621, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 3 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E688 Neighboring gene STARR-positive B cell enhancer ABC_E6491 Neighboring gene metaxin 1 pseudogene Neighboring gene DNA segment, Chr 6, Wayne State University 163, expressed Neighboring gene STARR-positive B cell enhancer ABC_E8131 Neighboring gene predicted gene 43124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal. Bridges AE, et al. Cancer Res, 2020 Sep 15. PMID 32665355, Free PMC Article
    2. The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway. Wang Y, et al. Neoplasma, 2023 Dec. PMID 37962862
    3. VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. Ku B, et al. PLoS Pathog, 2012. PMID 23271971, Free PMC Article
    4. RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. Bridges AE, et al. Mol Cancer Res, 2021 Sep. PMID 34099522, Free PMC Article
    5. Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Dray E, et al. Proc Natl Acad Sci U S A, 2011 Mar 1. PMID 21307306, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-kappaB signaling pathway.
      Title: The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
    2. RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
      Title: RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
    3. RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.
      Title: RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.
    4. VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
      Title: VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
    5. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.
      Title: Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-loop DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-loop DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA secondary structure binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA secondary structure binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within DNA recombination IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAD51-associated protein 1
    Names
    RAD51-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347455.1 → NP_001334384.1  RAD51-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1
      Source sequence(s)
      AK077829, AK079525, AW457762, BB620338
      Consensus CDS
      CCDS85161.1
      UniProtKB/Swiss-Prot
      O55219, Q8BP36, Q8C551, Q99L94, Q9D0J0
      UniProtKB/TrEMBL
      A0A0R4J1H1
      Related
      ENSMUSP00000107839.2, ENSMUST00000112220.8

    2. NM_009013.4 → NP_033039.2  RAD51-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_033039.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077829, AK079525, AW457762, BB620338
      Consensus CDS
      CCDS39644.1
      UniProtKB/Swiss-Prot
      O55219, Q8BP36, Q8C551, Q99L94, Q9D0J0
      UniProtKB/TrEMBL
      A0A0R4J1G4
      Related
      ENSMUSP00000107841.2, ENSMUST00000112221.8
      Conserved Domains (2) summary
      pfam10486
      Location:126 → 268
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
      pfam15696
      Location:293 → 331
      RAD51_interact; RAD51 interacting motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126900378..126916664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255239.1 → XP_030111099.1  RAD51-associated protein 1 isoform X1

      Conserved Domains (2) summary
      pfam10500
      Location:46 → 148
      SR-25; Nuclear RNA-splicing-associated protein
      pfam15696
      Location:193 → 231
      RAD51_interact; RAD51 interacting motif

    2. XM_030255240.1 → XP_030111100.1  RAD51-associated protein 1 isoform X1

      Conserved Domains (2) summary
      pfam10500
      Location:46 → 148
      SR-25; Nuclear RNA-splicing-associated protein
      pfam15696
      Location:193 → 231
      RAD51_interact; RAD51 interacting motif

    RNA

    1. XR_004942924.1 RNA Sequence

    2. XR_377433.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C551.2 GenPept UniProtKB/Swiss-Prot:Q8C551

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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