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    phoP two component system response transcriptional positive regulator PhoP [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888772, updated on 5-Jun-2024

    Summary

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    Gene symbol
    phoP
    Gene description
    two component system response transcriptional positive regulator PhoP
    Locus tag
    Rv0757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (851608..852351)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene tRNA-Thr Neighboring gene two component system response sensor kinase PhoR Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functioning of Mycobacterial Heat Shock Repressors Requires the Master Virulence Regulator PhoP. Sevalkar RR, et al. J Bacteriol, 2019 Jun 15. PMID 30962357, Free PMC Article
    2. Structure of the DNA-binding domain of the response regulator PhoP from Mycobacterium tuberculosis. Wang S, et al. Biochemistry, 2007 Dec 25. PMID 18052041, Free PMC Article
    3. A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. Chesne-Seck ML, et al. J Bacteriol, 2008 Feb. PMID 18065542, Free PMC Article
    4. PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation. Sinha A, et al. J Bacteriol, 2008 Feb. PMID 18065544, Free PMC Article
    5. PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. Gonzalo-Asensio J, et al. PLoS One, 2008. PMID 18946503, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional activation of the Mycobacterium tuberculosis virulence-associated small RNA MTS1338 by the response regulators DosR and PhoP.
      Title: Transcriptional activation of the Mycobacterium tuberculosis virulence-associated small RNA MTS1338 by the response regulators DosR and PhoP.
    2. PhoP, a virulence regulator of the tubercle bacilli, controls heat shock-responsive genes, an essential pathogenic determinant of M. tuberculosis
      Title: Functioning of Mycobacterial Heat Shock Repressors Requires the Master Virulence Regulator PhoP.
    3. Both MprA and PhoP can directly bind to the promoter of phoP and MprA positively regulates phoP expression. Reveal a new binding motif for MprA in the phoP promoter.
      Title: Novel MprA binding motifs in the phoP regulatory region in Mycobacterium tuberculosis.
    4. DevR forms a heterodimer with PhoPRv; puts forward a new possible mechanism for coordinated expression of the dormancy regulon
      Title: Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis.
    5. In this study, we found that PhoPR directly activates whiB3 expression in response to low pH.
      Title: PhoPR Positively Regulates whiB3 Expression in Response to Low pH in Pathogenic Mycobacteria.
    6. PhoP is essential for virulence as a response regulator involved in cell wall lipid biosynthesis and regulation of gene expression.[review]
      Title: [Mycobacterium tuberculosis PhoP system].
    7. a model is proposed suggesting how PhoP and EspR protein-protein interactions contribute to activation of espACD expression and, in turn, control ESAT-6 secretion, an essential pathogenic determinant of M. tuberculosis
      Title: EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP.
    8. EspR is directly regulated by the two-component systems MprAB and PhoPR.
      Title: EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR.
    9. Identified a high-affinity DNA sequence for PhoP binding using systematic evolution of ligands by exponential enrichment. The sequence contains a direct repeat of two 7 bp motifs separated by a 4 bp spacer, TCACAGC(N4)TCACAGC.
      Title: DNA consensus sequence motif for binding response regulator PhoP, a virulence regulator of Mycobacterium tuberculosis.
    10. DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system, were identified.
      Title: Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    two component system response transcriptional positive regulator PhoP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      851608..852351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215271.1 two component system response transcriptional positive regulator PhoP [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215271.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A655JDP8
      Conserved Domains (1) summary
      COG0745
      Location:22 → 246
      OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    Nucleotide Protein
    Heading Accession and Version

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