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    dnaK chaperone protein DnaK [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885946, updated on 6-Oct-2023

    Summary

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    Gene symbol
    dnaK
    Gene description
    chaperone protein DnaK
    Locus tag
    Rv0350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    hsp70
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    Genomic context

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    Sequence:
    NC_000962.3 (419835..421712)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene hypothetical protein Neighboring gene stress response protein GrpE Neighboring gene chaperone protein DnaJ Neighboring gene heat shock protein transcriptional repressor HspR Neighboring gene PPE family protein PPE7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype. Lopes RL, et al. PLoS One, 2014. PMID 25419575, Free PMC Article
    2. Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages. Hickey TB, et al. Infect Immun, 2009 Aug. PMID 19470749, Free PMC Article
    3. Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals. Bulut Y, et al. J Biol Chem, 2005 Jun 3. PMID 15809303
    4. DnaK dependence of the mycobacterial stress-responsive regulator HspR is mediated through its hydrophobic C-terminal tail. Bandyopadhyay B, et al. J Bacteriol, 2012 Sep. PMID 22753065, Free PMC Article
    5. Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones. Das Gupta T, et al. Microbiology (Reading), 2008 Feb. PMID 18227252

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DnaK-HspR-HAIR binding pattern altered at high temperatures in the presence of aggregated alpha-casein substrate, suggesting that DnaK may indirectly be responding to heat stress in a feedback loop mechanism.
      Title: Role of DnaK in HspR-HAIR interaction of Mycobacterium tuberculosis.
    2. Data indicate that DnaK induces activated macrophages (M2) phenotype surface markers.
      Title: Extracellular mycobacterial DnaK polarizes macrophages to the M2-like phenotype.
    3. The C-terminal hydrophobic tail of HspR was found to play a significant role in determining its thermal stability and DnaK dependence properties.
      Title: DnaK dependence of the mycobacterial stress-responsive regulator HspR is mediated through its hydrophobic C-terminal tail.
    4. These findings suggest that while M. tuberculosis displays both surface-associated Cpn60.2 and DnaK, only Cpn60.2 demonstrates adhesin functionality with regard to macrophage interaction.
      Title: Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages.
    5. Chemically denatured HspR was renatured, the protein gained optimal activity only if one of these GroEL class chaperones was present along with DnaK
      Title: Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones.
    6. HSP65 and HSP70 from Mycobacterium tuberculosis signal via TLR4
      Title: Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    chaperone protein DnaK
    NP_214864.1
    • heat shock protein 70 (heat shock 70 kDa protein) (HSP70)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      419835..421712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214864.1 chaperone protein DnaK [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214864.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0U1XGD1, B3VHV1
      Conserved Domains (1) summary
      PRK00290
      Location:1 → 600
      dnaK; molecular chaperone DnaK; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WMJ9.1

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