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    MARCHF7 membrane associated ring-CH-type finger 7 [ Homo sapiens (human) ]

    Gene ID: 64844, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MARCHF7provided by HGNC
    Official Full Name
    membrane associated ring-CH-type finger 7provided by HGNC
    Primary source
    HGNC:HGNC:17393
    See related
    Ensembl:ENSG00000136536 MIM:613334; AllianceGenome:HGNC:17393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AXO; AXOT; MARCH7; RNF177; MARCH-VII
    Summary
    MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 28.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MARCHF7 in Genome Data Viewer
    Location:
    2q24.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159712506..159771027)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160169869..160228395)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160569017..160627538)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene RPS3A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. Szigyarto CA, et al. J Histochem Cytochem, 2010 Apr. PMID 19901269, Free PMC Article
    2. Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer. Singh S, et al. Med Oncol, 2022 Dec 30. PMID 36583798
    3. Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus. Mahajan S, et al. J Gen Virol, 2021 Mar. PMID 33729124
    4. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination. Shi X, et al. Autophagy, 2024 Mar. PMID 37915253, Free PMC Article
    5. Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer. Zhang L, et al. Tohoku J Exp Med, 2016 Jul. PMID 27302477

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
      Title: Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
    2. Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer.
      Title: Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer.
    3. Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus.
      Title: Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus.
    4. Data show that miR-27b-3p inhibited ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7) in endometrial cancer (EC) cells and MARCH7 promoted cell invasion through snail transcription factors (Snail)-mediated pathway.
      Title: miR-27b-3p/MARCH7 regulates invasion and metastasis of endometrial cancer cells through Snail-mediated pathway.
    5. The findings uncover a novel mechanism for the regulation of Mdm2 and reveal MARCH7 as an important regulator of the Mdm2-p53 pathway.
      Title: Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.
    6. USP7 and MARCH7 are involved in the progression of Epithelial ovarian cancer.
      Title: Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
    7. Axotrophin/MARCH-7 has an expression profile that is distinct from that of other MARCH family members.
      Title: The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.
    8. MARCH7 can be stabilized by both USP9X and USP7, which deubiquitylate MARCH7 in the cytosol and nucleus, respectively
      Title: The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X.
    9. Data suggest that clinical auto-graft versus host disease inversely correlates with axotrophin transcript expression.
      Title: Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586F1122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tolerance induction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF7
    Names
    E3 ubiquitin-protein ligase MARCH7
    RING finger protein 177
    RING-type E3 ubiquitin transferase MARCH7
    RING-type E3 ubiquitin transferase MARCHF7
    axotrophin
    membrane associated ring finger 7
    membrane-associated RING finger protein 7
    membrane-associated RING-CH protein VII
    membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
    NP_001269734.1
    NP_001269735.1
    NP_001269736.1
    NP_001363163.1
    NP_001363164.1
    NP_001363165.1
    NP_001363166.1
    NP_001363167.1
    NP_001363168.1
    NP_001363169.1
    NP_001363170.1
    NP_001363171.1
    NP_001363172.1
    NP_001363173.1
    NP_001363174.1
    NP_001363175.1
    NP_001363176.1
    NP_001363177.1
    NP_001363178.1
    NP_001363179.1
    NP_001363180.1
    NP_001363181.1
    NP_001363182.1
    NP_001363183.1
    NP_001363184.1
    NP_073737.1
    XP_016860210.1
    XP_047301464.1
    XP_047301467.1
    XP_047301469.1
    XP_047301470.1
    XP_047301471.1
    XP_047301472.1
    XP_047301473.1
    XP_047301474.1
    XP_047301475.1
    XP_047301476.1
    XP_047301477.1
    XP_047301479.1
    XP_047301480.1
    XP_047301481.1
    XP_047301482.1
    XP_047301483.1
    XP_047301484.1
    XP_047301485.1
    XP_047301486.1
    XP_054199378.1
    XP_054199379.1
    XP_054199380.1
    XP_054199381.1
    XP_054199382.1
    XP_054199383.1
    XP_054199384.1
    XP_054199385.1
    XP_054199386.1
    XP_054199387.1
    XP_054199388.1
    XP_054199389.1
    XP_054199390.1
    XP_054199391.1
    XP_054199392.1
    XP_054199393.1
    XP_054199394.1
    XP_054199395.1
    XP_054199396.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282805.2 → NP_001269734.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      See identical proteins and their annotated locations for NP_001269734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-13 all encode the same isoform (a).
      Source sequence(s)
      AC009961, AI863394, AK292836, AK316382, BC003404
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Related
      ENSP00000386830.1, ENST00000409175.6
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001282806.2 → NP_001269735.1  E3 ubiquitin-protein ligase MARCHF7 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS63038.1
      UniProtKB/TrEMBL
      B7Z5K0, F5H6W4
      Related
      ENSP00000442992.1, ENST00000539065.5
      Conserved Domains (1) summary
      smart00744
      Location:496 → 552
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    3. NM_001282807.2 → NP_001269736.1  E3 ubiquitin-protein ligase MARCHF7 isoform c

      See identical proteins and their annotated locations for NP_001269736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC009961, AI863394, AK302347, AK316382, BC003404
      Consensus CDS
      CCDS63039.1
      UniProtKB/TrEMBL
      B7ZAR7
      Related
      ENSP00000387238.1, ENST00000409591.5
      Conserved Domains (1) summary
      smart00744
      Location:514 → 570
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    4. NM_001376234.1 → NP_001363163.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, and 6-13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. NM_001376235.1 → NP_001363164.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 5, and 7-13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. NM_001376236.1 → NP_001363165.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 5, 6, and 8-13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    7. NM_001376237.1 → NP_001363166.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 5-7, and 9-13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    8. NM_001376238.1 → NP_001363167.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 5-8, and 10-13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    9. NM_001376239.1 → NP_001363168.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, 5-9, and 11-13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    10. NM_001376240.1 → NP_001363169.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, 5-10, 12, and 13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    11. NM_001376241.1 → NP_001363170.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, 5-11, and 13, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    12. NM_001376242.1 → NP_001363171.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 2, and 5-10-12, encodes isoform a.
      Source sequence(s)
      AC009961
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    13. NM_001376243.1 → NP_001363172.1  E3 ubiquitin-protein ligase MARCHF7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:552 → 610
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    14. NM_001376244.1 → NP_001363173.1  E3 ubiquitin-protein ligase MARCHF7 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7Z5K0
      Conserved Domains (1) summary
      cd16812
      Location:552 → 610
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    15. NM_001376245.1 → NP_001363174.1  E3 ubiquitin-protein ligase MARCHF7 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7Z5K0
      Conserved Domains (1) summary
      cd16812
      Location:552 → 610
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    16. NM_001376246.1 → NP_001363175.1  E3 ubiquitin-protein ligase MARCHF7 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (2) summary
      cd00162
      Location:529 → 584
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:529 → 587
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    17. NM_001376247.1 → NP_001363176.1  E3 ubiquitin-protein ligase MARCHF7 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 19, encodes isoform g.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7Z5K0
      Conserved Domains (2) summary
      cd00162
      Location:496 → 551
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:496 → 554
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    18. NM_001376248.1 → NP_001363177.1  E3 ubiquitin-protein ligase MARCHF7 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variant 18, encodes isoform g.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7Z5K0
      Conserved Domains (2) summary
      cd00162
      Location:496 → 551
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:496 → 554
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    19. NM_001376249.1 → NP_001363178.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 21-23, encodes isoform h.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:423 → 481
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    20. NM_001376250.1 → NP_001363179.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 20, 22, and 23, encodes isoform h.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:423 → 481
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    21. NM_001376251.1 → NP_001363180.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 20, 21, and 23, encodes isoform h.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:423 → 481
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    22. NM_001376252.1 → NP_001363181.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 20-22, encodes isoform h.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:423 → 481
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    23. NM_001376253.1 → NP_001363182.1  E3 ubiquitin-protein ligase MARCHF7 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform i.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:423 → 481
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    24. NM_001376254.1 → NP_001363183.1  E3 ubiquitin-protein ligase MARCHF7 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform i.
      Source sequence(s)
      AC009961
      UniProtKB/TrEMBL
      B7ZAR7
      Conserved Domains (1) summary
      cd16812
      Location:423 → 481
      RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

    25. NM_001376255.1 → NP_001363184.1  E3 ubiquitin-protein ligase MARCHF7 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC009961
      Conserved Domains (2) summary
      cd00162
      Location:362 → 417
      RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
      cl17238
      Location:362 → 420
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    26. NM_022826.4 → NP_073737.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

      See identical proteins and their annotated locations for NP_073737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-13 all encode the same isoform (a).
      Source sequence(s)
      AC009961, AI863394, AK222880, AK316382, BC003404, DA825046
      Consensus CDS
      CCDS2210.1
      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
      UniProtKB/TrEMBL
      B7ZAR7
      Related
      ENSP00000259050.3, ENST00000259050.8
      Conserved Domains (1) summary
      cl17238
      Location:552 → 610
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. NR_164789.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    2. NR_164790.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    3. NR_164791.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    4. NR_164792.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    5. NR_164793.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    6. NR_164794.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    7. NR_164795.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009961

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      159712506..159771027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445513.1 → XP_047301469.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

    2. XM_047445518.1 → XP_047301474.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    3. XM_047445527.1 → XP_047301483.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    4. XM_047445516.1 → XP_047301472.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    5. XM_047445524.1 → XP_047301480.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    6. XM_047445517.1 → XP_047301473.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    7. XM_047445525.1 → XP_047301481.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    8. XM_047445530.1 → XP_047301486.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

      UniProtKB/TrEMBL
      F5H6W4

    9. XM_047445526.1 → XP_047301482.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    10. XM_017004721.2 → XP_016860210.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

      UniProtKB/TrEMBL
      B7Z5K0, F5H6W4
      Conserved Domains (1) summary
      smart00744
      Location:496 → 552
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    11. XM_047445508.1 → XP_047301464.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

    12. XM_047445521.1 → XP_047301477.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    13. XM_047445529.1 → XP_047301485.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    14. XM_047445519.1 → XP_047301475.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    15. XM_047445520.1 → XP_047301476.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    16. XM_047445528.1 → XP_047301484.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    17. XM_047445511.1 → XP_047301467.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

    18. XM_047445514.1 → XP_047301470.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

    19. XM_047445523.1 → XP_047301479.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    20. XM_047445515.1 → XP_047301471.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      UniProtKB/Swiss-Prot
      A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      160169869..160228395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343405.1 → XP_054199380.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    2. XM_054343409.1 → XP_054199384.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    3. XM_054343417.1 → XP_054199392.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    4. XM_054343407.1 → XP_054199382.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    5. XM_054343414.1 → XP_054199389.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    6. XM_054343408.1 → XP_054199383.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    7. XM_054343415.1 → XP_054199390.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    8. XM_054343421.1 → XP_054199396.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

    9. XM_054343416.1 → XP_054199391.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    10. XM_054343420.1 → XP_054199395.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

    11. XM_054343403.1 → XP_054199378.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    12. XM_054343412.1 → XP_054199387.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    13. XM_054343419.1 → XP_054199394.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    14. XM_054343410.1 → XP_054199385.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    15. XM_054343411.1 → XP_054199386.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    16. XM_054343418.1 → XP_054199393.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

    17. XM_054343404.1 → XP_054199379.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    18. XM_054343413.1 → XP_054199388.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

    19. XM_054343406.1 → XP_054199381.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H992.1 GenPept UniProtKB/Swiss-Prot:Q9H992

    Gene LinkOut

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