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    Siva1 SIVA1, apoptosis-inducing factor [ Mus musculus (house mouse) ]

    Gene ID: 30954, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Siva1provided by MGI
    Official Full Name
    SIVA1, apoptosis-inducing factorprovided by MGI
    Primary source
    MGI:MGI:1353606
    See related
    Ensembl:ENSMUSG00000064326 AllianceGenome:MGI:1353606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siva; CD27bp
    Summary
    Enables CD27 receptor binding activity; tumor necrosis factor receptor binding activity; and virus receptor activity. Predicted to be involved in several processes, including activation-induced cell death of T cells; apoptotic signaling pathway; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SIVA1 (SIVA1 apoptosis inducing factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.8), ovary adult (RPKM 52.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Siva1 in Genome Data Viewer
    Location:
    12 F1; 12 61.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112611262..112615586)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112644828..112649152)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene STARR-positive B cell enhancer ABC_E601 Neighboring gene predicted gene, 30101 Neighboring gene thymoma viral proto-oncogene 1 Neighboring gene microRNA 6939 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113913641-113913750 Neighboring gene predicted gene, 30150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine Siva-1 and Siva-2, alternate splice forms of the mouse Siva gene, both bind to CD27 but differentially transduce apoptosis. Yoon Y, et al. Oncogene, 1999 Nov 25. PMID 10597319
    2. Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva. Henke A, et al. J Virol, 2000 May. PMID 10756043, Free PMC Article
    3. SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis. Cottle DL, et al. J Biol Chem, 2009 Sep 25. PMID 19643733, Free PMC Article
    4. The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva. Henke A, et al. Virology, 2001 Oct 10. PMID 11601913
    5. Siva plays a critical role in mouse embryonic development. Jacobs SBR, et al. Cell Death Differ, 2020 Jan. PMID 31164717, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Siva plays a critical role in mouse embryonic development.
      Title: Siva plays a critical role in mouse embryonic development.
    2. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
      Title: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
    3. These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
      Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
    4. Data indicate that p53 target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
      Title: p53 target Siva regulates apoptosis in ischemic kidneys.
    5. Data show that SLIMMER delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
      Title: SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
    6. lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
      Title: The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.
    7. SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1
      Title: The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.
    8. Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53-dependent apoptosis in cerebellar granule neurons.
      Title: Siva is an apoptosis-selective p53 target gene important for neuronal cell death.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD27 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CD27 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables CD27 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis regulatory protein Siva
    Names
    CD27-binding protein
    Cd27 binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161737.1 → NP_001155209.1  apoptosis regulatory protein Siva isoform 2

      See identical proteins and their annotated locations for NP_001155209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC124373, AF033112, AW060433, CB524656
      Consensus CDS
      CCDS49189.1
      UniProtKB/Swiss-Prot
      O54926
      Related
      ENSMUSP00000105377.4, ENSMUST00000109755.5
      Conserved Domains (1) summary
      pfam05458
      Location:1 → 110
      Siva; Cd27 binding protein (Siva)

    2. NM_013929.2 → NP_038957.2  apoptosis regulatory protein Siva isoform 1

      See identical proteins and their annotated locations for NP_038957.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124373, AK017570, AW060433, CB524656
      Consensus CDS
      CCDS26193.1
      UniProtKB/Swiss-Prot
      O54926, Q3U6J2, Q921I8, Q9CWL1, Q9R1Q0, Q9R1Q1
      UniProtKB/TrEMBL
      Q3TFC3
      Related
      ENSMUSP00000021728.5, ENSMUST00000021728.12
      Conserved Domains (1) summary
      pfam05458
      Location:1 → 175
      Siva; Cd27 binding protein (Siva)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112611262..112615586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54926.1 GenPept UniProtKB/Swiss-Prot:O54926

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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