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    Nol8 nucleolar protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 70930, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nol8provided by MGI
    Official Full Name
    nucleolar protein 8provided by MGI
    Primary source
    MGI:MGI:1918180
    See related
    Ensembl:ENSMUSG00000021392 AllianceGenome:MGI:1918180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921532D18Rik; 5730412B09Rik
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromosome. Predicted to be active in nucleolus. Is expressed in central nervous system and sensory organ. Orthologous to human NOL8 (nucleolar protein 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 5.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nol8 in Genome Data Viewer
    Location:
    13 A5; 13 25.36 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49806554..49832492)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49653078..49679016)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene STARR-seq mESC enhancer starr_34480 Neighboring gene osteomodulin Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene STARR-positive B cell enhancer ABC_E8527 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene predicted gene, 23482

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein localization to nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271397.1 → NP_001258326.1  nucleolar protein 8

      See identical proteins and their annotated locations for NP_001258326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein.
      Source sequence(s)
      AK014994, AK147172, BC125575
      Consensus CDS
      CCDS36658.1
      UniProtKB/TrEMBL
      E9QKD1
      Related
      ENSMUSP00000152536.2, ENSMUST00000222197.2
      Conserved Domains (1) summary
      cd12226
      Location:27 → 106
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    RNA

    1. NR_073167.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK014994, AK147172, BC058699

    2. NR_073168.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC160978, AK014994, AK147172

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49806554..49832492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516956.3 → XP_006517019.2  nucleolar protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006517019.2

      UniProtKB/Swiss-Prot
      Q059P5, Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0
      Related
      ENSMUSP00000152878.2, ENSMUST00000223467.2
      Conserved Domains (1) summary
      cd12226
      Location:9 → 88
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    2. XM_006516958.5 → XP_006517021.1  nucleolar protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006517021.1

      UniProtKB/TrEMBL
      E9QKD1
      Conserved Domains (1) summary
      cd12226
      Location:27 → 106
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    3. XM_006516957.1 → XP_006517020.1  nucleolar protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006517020.1

      UniProtKB/TrEMBL
      E9QKD1
      Related
      ENSMUSP00000021824.8, ENSMUST00000021824.8
      Conserved Domains (1) summary
      cd12226
      Location:27 → 106
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081350.1: Suppressed sequence

      Description
      NM_001081350.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHX0.2 GenPept UniProtKB/Swiss-Prot:Q3UHX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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