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    KIF9 kinesin family member 9 [ Homo sapiens (human) ]

    Gene ID: 64147, updated on 14-Nov-2024

    Summary

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    Official Symbol
    KIF9provided by HGNC
    Official Full Name
    kinesin family member 9provided by HGNC
    Primary source
    HGNC:HGNC:16666
    See related
    Ensembl:ENSG00000088727 MIM:607910; AllianceGenome:HGNC:16666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables identical protein binding activity. Involved in extracellular matrix disassembly; organelle disassembly; and regulation of podosome assembly. Located in microtubule; podosome; and vesicle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 11.7), thyroid (RPKM 1.7) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF9 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (47227998..47282799, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (47244385..47299181, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47269488..47324289, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47082829-47083038 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 3 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47108907-47109512 Neighboring gene NANOG hESC enhancer GRCh37_chr3:47125242-47125743 Neighboring gene uncharacterized LOC124906375 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155200-47155707 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155708-47156216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19809 Neighboring gene KIF9 antisense RNA 1 Neighboring gene MPRA-validated peak4632 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47238926-47239426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:47301362-47302268 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 13J Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:47323613-47324812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14308 Neighboring gene kelch like family member 18 Neighboring gene Sharpr-MPRA regulatory region 13740 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:47403837-47405036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47421897-47422574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:47422575-47423250 Neighboring gene PTPN23 divergent transcript Neighboring gene protein tyrosine phosphatase non-receptor type 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families. Meng Z, et al. Front Endocrinol (Lausanne), 2022. PMID 36686457, Free PMC Article
    2. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. Piddini E, et al. EMBO J, 2001 Aug 1. PMID 11483511, Free PMC Article
    3. The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression. Andrieu G, et al. FASEB J, 2012 Dec. PMID 22964304
    4. The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Cornfine S, et al. Mol Biol Cell, 2011 Jan 15. PMID 21119006, Free PMC Article
    5. Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. Armstrong LA, et al. PLoS One, 2021. PMID 34270554, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families.
      Title: Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families.
    2. Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9.
      Title: The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression.
    3. kinesin KIF9 and reggie/flotillin proteins are novel regulators of macrophage podosomes and their interaction is critical for podosomal matrix-degradation
      Title: The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC104186

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organelle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF9
    Names
    kinesin protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134878.3 → NP_001128350.1  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_001128350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC104447, AI741745, AK292547, AK314418
      Consensus CDS
      CCDS2752.1
      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000391100.2, ENST00000452770.6
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain

    2. NM_001377474.1 → NP_001364403.1  kinesin-like protein KIF9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (1) summary
      cl22853
      Location:6 → 263
      Motor_domain; Myosin and Kinesin motor domain

    3. NM_001377475.1 → NP_001364404.1  kinesin-like protein KIF9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (1) summary
      cl22853
      Location:6 → 263
      Motor_domain; Myosin and Kinesin motor domain

    4. NM_001377476.1 → NP_001364405.1  kinesin-like protein KIF9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104447
      Consensus CDS
      CCDS93262.1
      UniProtKB/TrEMBL
      E7EUW8, Q6PJI1
      Related
      ENSP00000391099.1, ENST00000432493.5
      Conserved Domains (1) summary
      cl22853
      Location:6 → 89
      Motor_domain; Myosin and Kinesin motor domain

    5. NM_001377477.1 → NP_001364406.1  kinesin-like protein KIF9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104447
      Consensus CDS
      CCDS93262.1
      UniProtKB/TrEMBL
      E7EUW8, Q6PJI1
      Related
      ENSP00000406815.1, ENST00000425853.5
      Conserved Domains (1) summary
      cl22853
      Location:6 → 89
      Motor_domain; Myosin and Kinesin motor domain

    6. NM_001413975.1 → NP_001400904.1  kinesin-like protein KIF9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104447

    7. NM_001413976.1 → NP_001400905.1  kinesin-like protein KIF9 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC104447

    8. NM_022342.6 → NP_071737.1  kinesin-like protein KIF9 isoform 1

      See identical proteins and their annotated locations for NP_071737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AC104447, AF311212, AI741745, AK292547
      Consensus CDS
      CCDS2751.1
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000414987.2, ENST00000444589.6
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain

    9. NM_182902.4 → NP_878905.2  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_878905.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the mid coding region, compared to variant 1, and encodes an isoform (2) that is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC104447, AI741745, AK292547, AK314418, BC030657
      Consensus CDS
      CCDS2752.1
      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000507186.1, ENST00000684063.1
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      47227998..47282799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448712.1 → XP_047304668.1  kinesin-like protein KIF9 isoform X6

    2. XM_006713291.4 → XP_006713354.1  kinesin-like protein KIF9 isoform X4

      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cl22853
      Location:39 → 296
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:45 → 298
      Kinesin; Kinesin motor domain

    3. XM_005265389.5 → XP_005265446.1  kinesin-like protein KIF9 isoform X2

      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cd01375
      Location:39 → 371
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:45 → 373
      Kinesin; Kinesin motor domain

    4. XM_047448709.1 → XP_047304665.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2

    5. XM_017007029.2 → XP_016862518.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain

    6. XM_047448711.1 → XP_047304667.1  kinesin-like protein KIF9 isoform X5

    7. XM_011534007.3 → XP_011532309.1  kinesin-like protein KIF9 isoform X8

    8. XM_047448710.1 → XP_047304666.1  kinesin-like protein KIF9 isoform X3

    9. XM_047448713.1 → XP_047304669.1  kinesin-like protein KIF9 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      47244385..47299181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347531.1 → XP_054203506.1  kinesin-like protein KIF9 isoform X6

    2. XM_054347529.1 → XP_054203504.1  kinesin-like protein KIF9 isoform X4

    3. XM_054347527.1 → XP_054203502.1  kinesin-like protein KIF9 isoform X2

    4. XM_054347525.1 → XP_054203500.1  kinesin-like protein KIF9 isoform X1

    5. XM_054347526.1 → XP_054203501.1  kinesin-like protein KIF9 isoform X1

    6. XM_054347530.1 → XP_054203505.1  kinesin-like protein KIF9 isoform X5

    7. XM_054347533.1 → XP_054203508.1  kinesin-like protein KIF9 isoform X8

    8. XM_054347528.1 → XP_054203503.1  kinesin-like protein KIF9 isoform X3

    9. XM_054347532.1 → XP_054203507.1  kinesin-like protein KIF9 isoform X7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182903.2: Suppressed sequence

      Description
      NM_182903.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HAQ2.4 GenPept UniProtKB/Swiss-Prot:Q9HAQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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