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    Zfp560 zinc finger protein 560 [ Mus musculus (house mouse) ]

    Gene ID: 434377, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zfp560provided by MGI
    Official Full Name
    zinc finger protein 560provided by MGI
    Primary source
    MGI:MGI:1915280
    See related
    Ensembl:ENSMUSG00000045519 AllianceGenome:MGI:1915280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf560; 2310030G09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF560 (zinc finger protein 560). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E18 (RPKM 3.2), CNS E14 (RPKM 2.9) and 24 other tissues See more
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    Genomic context

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    See Zfp560 in Genome Data Viewer
    Location:
    9 A3; 9 7.52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20256432..20296479, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20345136..20385182, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 177 Neighboring gene STARR-seq mESC enhancer starr_23456 Neighboring gene olfactory receptor family 7 subfamily E member 178 Neighboring gene STARR-positive B cell enhancer ABC_E9752 Neighboring gene zinc finger protein 26 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene zinc finger protein 426 Neighboring gene predicted gene, 23316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 778

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004190.4 → NP_001004190.2  zinc finger protein 778

      See identical proteins and their annotated locations for NP_001004190.2

      Status: VALIDATED

      Source sequence(s)
      AC166098
      Consensus CDS
      CCDS22877.1
      UniProtKB/TrEMBL
      Q3URI6
      Related
      ENSMUSP00000065620.8, ENSMUST00000068079.14
      Conserved Domains (6) summary
      smart00349
      Location:41 → 97
      KRAB; krueppel associated box
      COG5048
      Location:276 → 689
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:617 → 637
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:41 → 80
      KRAB; KRAB box
      pfam13465
      Location:293 → 318
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20256432..20296479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244440.2 → XP_030100300.1  zinc finger protein 778 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:70 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:411 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030244441.2 → XP_030100301.1  zinc finger protein 778 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:70 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:411 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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