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    COPZ2 COPI coat complex subunit zeta 2 [ Homo sapiens (human) ]

    Gene ID: 51226, updated on 6-Jun-2024

    Summary

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    Official Symbol
    COPZ2provided by HGNC
    Official Full Name
    COPI coat complex subunit zeta 2provided by HGNC
    Primary source
    HGNC:HGNC:19356
    See related
    Ensembl:ENSG00000005243 MIM:615526; AllianceGenome:HGNC:19356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    zeta2-COP
    Summary
    This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in fat (RPKM 13.1), prostate (RPKM 4.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See COPZ2 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48026167..48048053, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48887980..48909899, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46103533..46115159, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46048841-46049468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46052765-46053265 Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46072377-46072975 Neighboring gene Sharpr-MPRA regulatory region 8372 Neighboring gene uncharacterized LOC124904017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46092391-46092892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46092893-46093392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46103594-46104152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46104153-46104709 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:46105093-46105359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12323 Neighboring gene microRNA 10226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:46124493-46125096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:46125097-46125698 Neighboring gene microRNA 152 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:46125699-46126300 Neighboring gene NFE2L1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46131609-46132468 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46133329-46134186 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46134187-46135046 Neighboring gene NFE2 like bZIP transcription factor 1 Neighboring gene chromobox 1 Neighboring gene RNA, U6 small nuclear 1201, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1. Shtutman M, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746916, Free PMC Article
    2. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. Yu W, et al. J Mol Biol, 2009 Mar 6. PMID 19167404
    3. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Sullivan BM, et al. Mol Biol Cell, 2000 Sep. PMID 10982407, Free PMC Article
    4. Identification and characterization of novel isoforms of COP I subunits. Futatsumori M, et al. J Biochem, 2000 Nov. PMID 11056392
    5. In vivo assembly of coatomer, the COP-I coat precursor. Lowe M, et al. J Biol Chem, 1996 Nov 29. PMID 8940050

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The knockdown of COPZ1, but not of COPZ2 encoding isoform coatomer protein complex zeta2, caused Golgi apparatus collapse, blocked autophagy, and induced apoptosis in both proliferating and nondividing tumor cells.
      Title: Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.
    2. The solution structure of a truncated form (residues 1-149; zeta-COP149) of human zeta-COP (total 177 residues), is reported.
      Title: Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC23008

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cis-Golgi network NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit zeta-2
    Names
    coatomer protein complex subunit zeta 2
    nonclathrin coat protein zeta-COP
    zeta-2 COP
    zeta-2-coat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016429.4 → NP_057513.1  coatomer subunit zeta-2

      See identical proteins and their annotated locations for NP_057513.1

      Status: REVIEWED

      Source sequence(s)
      BC015924, BQ002984, HY179834
      Consensus CDS
      CCDS74092.1
      UniProtKB/Swiss-Prot
      Q9P299
      Related
      ENSP00000480707.1, ENST00000621465.5
      Conserved Domains (1) summary
      cd14829
      Location:47 → 178
      Zeta-COP; zeta subunit of the F-COPI complex

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      48026167..48048053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524874.3 → XP_011523176.1  coatomer subunit zeta-2 isoform X4

      Conserved Domains (1) summary
      cl38905
      Location:47 → 152
      longin-like; Longin-like domains

    2. XM_047436209.1 → XP_047292165.1  coatomer subunit zeta-2 isoform X5

      UniProtKB/TrEMBL
      J3QS21
      Related
      ENSP00000464484.1, ENST00000584955.5

    3. XM_047436207.1 → XP_047292163.1  coatomer subunit zeta-2 isoform X2

    4. XM_047436208.1 → XP_047292164.1  coatomer subunit zeta-2 isoform X3

    5. XM_047436206.1 → XP_047292162.1  coatomer subunit zeta-2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      48887980..48909899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316365.1 → XP_054172340.1  coatomer subunit zeta-2 isoform X4

    2. XM_054316366.1 → XP_054172341.1  coatomer subunit zeta-2 isoform X5

      UniProtKB/TrEMBL
      J3QS21

    3. XM_054316363.1 → XP_054172338.1  coatomer subunit zeta-2 isoform X2

    4. XM_054316364.1 → XP_054172339.1  coatomer subunit zeta-2 isoform X3

    5. XM_054316362.1 → XP_054172337.1  coatomer subunit zeta-2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P299.1 GenPept UniProtKB/Swiss-Prot:Q9P299

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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