Agtr1b angiotensin II receptor, type 1b [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agtr1bprovided by RGD
Official Full Name: angiotensin II receptor, type 1bprovided by RGD
Primary source: RGD:2071
See related: EnsemblRapid:ENSRNOG00000010640 AllianceGenome:RGD:2071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AT1; AT3; AT1B; Agtr1; AT<sub>1</sub>R
Summary: Predicted to enable angiotensin type I receptor activity. Involved in several processes, including angiotensin-activated signaling pathway; cellular response to dexamethasone stimulus; and positive regulation of branching involved in ureteric bud morphogenesis. Predicted to be active in plasma membrane. Biomarker of hypertension and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 79.0), Kidney (RPKM 22.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (104774005..104849262, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (102844969..102920232, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (105149020..105224335, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy.
Title: The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy.
Inhibition of angiotensin II type 1 receptor reduces oxidative stress damage to the intestinal barrier in severe acute pancreatitis.
Title: Inhibition of angiotensin II type 1 receptor reduces oxidative stress damage to the intestinal barrier in severe acute pancreatitis.
Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical Reconstruction Microscopy (dSTORM).
Title: Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical Reconstruction Microscopy (dSTORM).
Major components of the renin angiotensin system are located in striatal projection neurons, and striatal astrocytes and microglial cells of rats.
Title: Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells.
A counterregulatory interaction between dopamine and the angiotensin receptor was observed.
Title: Aging-related dysregulation of dopamine and angiotensin receptor interaction.
The enhanced downregulation of the AT1-B receptors in the renin-positive SMCs in the arterioles may result in an enhanced level of renin granulation in the arterioles.
Title: Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys.
Data indicate that mRNA of tissue renin-angiotensin system (tRAS) components angiotensin converting enzyme, Ang II, Ang II receptor type 1, Ang II receptor type 2, and Cathepsin D in intervertebral disc (IVD) was clearly confirmed BY RT-PCR.
Title: Tissue renin-angiotensin system in the intervertebral disc.
Data indicate tjat AT1 receptor blockade completely abrogated AT1-AA-induced TNF-alpha secretion, caspase-3 activation, and cardiomyocyte apoptosis.
Title: Angiotensin II type I receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-α.
alterations in both D1R (diminished) and AT(1)R (exaggerated) functions are necessary for the development of age-associated hypertension, as seen in old FBN rats.
Title: Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
Data demonstrate tissue-specific changes in AT1a-b and AT2 receptor expression after myocardial infarction, and show that MI has a strong influence on the expression of angiotensin receptor type AT1 in the prostate at the protein and mRNA level.
Title: Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Agtr1a (e-PCR), detects polymorphism
- UniSTS:516680

D2Mco34 (e-PCR)
- UniSTS:239452

D2Mco35 (e-PCR)
- UniSTS:239453

UniSTS:256385 (e-PCR)
- UniSTS:256385

Agtr1a (e-PCR), detects polymorphism
- UniSTS:256385

UniSTS:256387 (e-PCR)
- UniSTS:256387

Agtr1b (e-PCR), detects polymorphism
- UniSTS:256387

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables angiotensin type I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin type I receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables angiotensin type I receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables angiotensin type II receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within brain renin-angiotensin system	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of renal output by angiotensin	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: type-1 angiotensin II receptor B

Names: AT1 receptor B; Angiotensin II receptor, type 1 (AT1B); angiotensin II receptor, type-1; angiotensin II type-1 receptor; angiotensin II type-1 receptor B; angiotensin II type-1B receptor; angiotensin receptor 1; angiotensin receptor 1b; type-1B angiotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.