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    Gpr146 G protein-coupled receptor 146 [ Mus musculus (house mouse) ]

    Gene ID: 80290, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gpr146provided by MGI
    Official Full Name
    G protein-coupled receptor 146provided by MGI
    Primary source
    MGI:MGI:1933113
    See related
    Ensembl:ENSMUSG00000044197 AllianceGenome:MGI:1933113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR8; D830046C22Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Located in plasma membrane. Orthologous to human GPR146 (G protein-coupled receptor 146). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in lung adult (RPKM 19.7), mammary gland adult (RPKM 13.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr146 in Genome Data Viewer
    Location:
    5 G2; 5 78.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139363452..139382170)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139377697..139396415)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082I17 gene Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1 Neighboring gene microRNA 339 Neighboring gene STARR-positive B cell enhancer ABC_E9657 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:139858915-139859024 Neighboring gene RIKEN cDNA C130050O18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:139894778-139894979 Neighboring gene G protein-coupled estrogen receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice. Han F, et al. Cell Res, 2020 Apr. PMID 32203133, Free PMC Article
    2. Investigation into the presence and functional significance of proinsulin C-peptide in the female germline†. Martin JH, et al. Biol Reprod, 2019 May 1. PMID 30715203
    3. GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase. Huang J, et al. Eur J Pharmacol, 2023 Dec 15. PMID 37926274
    4. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Yu H, et al. Cell, 2019 Nov 27. PMID 31778654, Free PMC Article
    5. Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway. Huang H, et al. Immunology, 2017 Sep. PMID 28464285, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
      Title: GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
    2. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.
      Title: Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.
    3. these findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism.
      Title: GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.
    4. GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling.
      Title: Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC7035, MGC182532, MGC182544

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 146

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038703.3 → NP_001033792.1  probable G-protein coupled receptor 146

      See identical proteins and their annotated locations for NP_001033792.1

      Status: VALIDATED

      Source sequence(s)
      AC140216
      Consensus CDS
      CCDS19809.1
      UniProtKB/Swiss-Prot
      Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
      UniProtKB/TrEMBL
      Q3U2L7
      Related
      ENSMUSP00000098083.3, ENSMUST00000100514.3
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001362206.1 → NP_001349135.1  probable G-protein coupled receptor 146

      Status: VALIDATED

      Source sequence(s)
      AC140216, AC161058
      Consensus CDS
      CCDS19809.1
      UniProtKB/Swiss-Prot
      Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
      UniProtKB/TrEMBL
      Q3U2L7
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_030258.5 → NP_084534.2  probable G-protein coupled receptor 146

      See identical proteins and their annotated locations for NP_084534.2

      Status: VALIDATED

      Source sequence(s)
      AC161058, AK155876, BB738958
      Consensus CDS
      CCDS19809.1
      UniProtKB/Swiss-Prot
      Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
      UniProtKB/TrEMBL
      Q3U2L7
      Related
      ENSMUSP00000049707.8, ENSMUST00000051293.8
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_033147.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant is represented as non-coding because it lacks the open reading frame found in the other variants.
      Source sequence(s)
      AK086028, AK087317
      Related
      ENSMUST00000188655.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139363452..139382170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254916.2 → XP_030110776.1  probable G-protein coupled receptor 146 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
      UniProtKB/TrEMBL
      Q3U2L7
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177097.3: Suppressed sequence

      Description
      NM_177097.3: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LE2.2 GenPept UniProtKB/Swiss-Prot:Q99LE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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