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    Zbtb4 zinc finger and BTB domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 75580, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zbtb4provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 4provided by MGI
    Primary source
    MGI:MGI:1922830
    See related
    Ensembl:ENSMUSG00000018750 AllianceGenome:MGI:1922830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1538; 2310026P19Rik; 9230111I22Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleotide binding activity; and protein homodimerization activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human ZBTB4 (zinc finger and BTB domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 27.8), mammary gland adult (RPKM 15.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb4 in Genome Data Viewer
    Location:
    11 B3; 11 42.87 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69656738..69674852)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69765912..69784026)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide A Neighboring gene STARR-positive B cell enhancer ABC_E3966 Neighboring gene STARR-positive B cell enhancer ABC_E1830 Neighboring gene solute carrier family 35, member G3 Neighboring gene STARR-seq mESC enhancer starr_29866 Neighboring gene STARR-seq mESC enhancer starr_29867 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E7006 Neighboring gene fibroblast growth factor 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury. Wu H, et al. Brain Res Bull, 2024 Jun 15. PMID 38641154
    2. Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis. Roussel-Gervais A, et al. Cancer Res, 2017 Jan 1. PMID 27815388
    3. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. Barrett CW, et al. PLoS One, 2012. PMID 23251453, Free PMC Article
    4. Discovery and validation of genes driving drug-intake and related behavioral traits in mice. Roy TA, et al. Genes Brain Behav, 2024 Jan 2. PMID 38164795, Free PMC Article
    5. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
      Title: MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury.
    2. we provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties
      Title: Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpNpG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpNpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363178.1 → NP_001350107.1  zinc finger and BTB domain-containing protein 4

      Status: VALIDATED

      Source sequence(s)
      AL603707
      Consensus CDS
      CCDS36197.2
      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Related
      ENSMUSP00000104280.2, ENSMUST00000108640.8
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    2. NM_029348.2 → NP_083624.2  zinc finger and BTB domain-containing protein 4

      See identical proteins and their annotated locations for NP_083624.2

      Status: VALIDATED

      Source sequence(s)
      AK147212, BE943927, CA325272, CJ106077
      Consensus CDS
      CCDS36197.2
      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Related
      ENSMUSP00000104279.2, ENSMUST00000108639.8
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69656738..69674852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249293.3 → XP_011247595.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011247595.1

      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    2. XM_006534390.4 → XP_006534453.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006534453.1

      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    3. XM_006534394.5 → XP_006534457.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006534457.1

      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    4. XM_006534391.5 → XP_006534454.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006534454.1

      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    5. XM_006534389.4 → XP_006534452.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006534452.1

      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type

    6. XM_006534393.5 → XP_006534456.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006534456.1

      UniProtKB/Swiss-Prot
      Q3UHT8, Q5F293, Q69ZH0
      Conserved Domains (5) summary
      sd00017
      Location:287 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:739 → 761
      zf-C2H2; Zinc finger, C2H2 type
      cd18195
      Location:12 → 160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam13913
      Location:211 → 233
      zf-C2HC_2; zinc-finger of a C2HC-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F293.1 GenPept UniProtKB/Swiss-Prot:Q5F293

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