Adgrb3 adhesion G protein-coupled receptor B3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrb3provided by MGI
Official Full Name: adhesion G protein-coupled receptor B3provided by MGI
Primary source: MGI:MGI:2441837
See related: Ensembl:ENSMUSG00000033569 AllianceGenome:MGI:2441837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bai3; A830096D10Rik
Summary: Enables GTPase activator activity. Involved in regulation of dendrite morphogenesis; regulation of synapse maturation; and regulation of synapse pruning. Acts upstream of or within several processes, including motor learning; neuron remodeling; and positive regulation of synapse assembly. Located in postsynapse and synaptic cleft. Is active in cerebellar climbing fiber to Purkinje cell synapse and postsynaptic density membrane. Is expressed in several structures, including brain; lung; skeletal muscle; and testis. Orthologous to human ADGRB3 (adhesion G protein-coupled receptor B3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in CNS E18 (RPKM 11.3), cerebellum adult (RPKM 9.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A5; 1 10.39 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (25106557..25869338, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (25067476..25834772, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice.
Title: Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice.
Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.
Title: Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.
The secreted complement component 1, q subcomponent-like protein 4 (C1qL4) repress myoblast fusion by specifically interacting with G protein-coupled receptor BAI3 (BAI3). Stabilin-2 interacts with BAI3 and stimulates its fusion promoting activity. The resulting activated heterotrimeric G-proteins contribute to the initial recruitment of Elmo proteins to the membrane, which are then stabilized on BAI3.
Title: Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.
Signal transduction via C1qL1-BAI3 interaction is required for motor learning, triggers pruting of surplus cerebellar climbing fibers, and is required to maintain climbing fiber synapses.
Title: Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.
G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.
Title: G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.
results reveal that the BAI3 receptor controls dendritic arborization growth and branching in cultured neurons.
Title: The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons.
Two transcripts with significant regulation from days 7 to 28 in the 1-methyl-4-phenyl-tetrahydropyridine treated groups are identified: brain specific angiogenesis inhibitor associated protein 3 (Baiap3) and breast carcinoma amplified sequence 1 (Bcas1).
Title: Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity.
C1ql proteins are secreted signaling molecules that bind to BAI3 and act, at least in part, to regulate synapse formation and/or maintenance.
Title: The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation
Transposon induced (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit211 (e-PCR), detects polymorphism
- UniSTS:128553

Bai3 (e-PCR), detects polymorphism
- UniSTS:477290

Bai3 (e-PCR), detects polymorphism
- UniSTS:474763

MHAa7c1.seq (e-PCR)
- UniSTS:125341

Bai3 (e-PCR), detects polymorphism
- UniSTS:532663

D1Mit363 (e-PCR), detects polymorphism
- UniSTS:128722

BAI3_3939 (e-PCR)
- UniSTS:462052

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of synapse structure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor learning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron remodeling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse pruning	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adhesion G protein-coupled receptor B3

Names: G protein-coupled receptor BAI3; brain-specific angiogenesis inhibitor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175642.4 → NP_783573.4 adhesion G protein-coupled receptor B3 precursor

See identical proteins and their annotated locations for NP_783573.4

Status: VALIDATED

Source sequence(s)

AC116556, AK044248, AK129162, BC032251

Consensus CDS

CCDS14855.1

UniProtKB/Swiss-Prot

G3XA05, Q80ZF8

UniProtKB/TrEMBL

Q499E3

Related

ENSMUSP00000116231.2, ENSMUST00000151309.8

Conserved Domains (5) summary

smart00303
Location:816 → 867

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:510 → 576

HormR; Domain present in hormone receptors

smart00209
Location:348 → 398

TSP1; Thrombospondin type 1 repeats

cd15989
Location:872 → 1164

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:594 → 794

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

25106557..25869338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163215.1 → XP_036019108.1 adhesion G protein-coupled receptor B3 isoform X3

UniProtKB/TrEMBL

Q499E3

Conserved Domains (6) summary

smart00303
Location:779 → 830

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:473 → 539

HormR; Domain present in hormone receptors

smart00209
Location:311 → 361

TSP1; Thrombospondin type 1 repeats

cd15989
Location:835 → 1127

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:557 → 757

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

pfam19188
Location:29 → 203

AGRB_N; Adhesion GPCR B N-terminal region
XM_036163213.1 → XP_036019106.1 adhesion G protein-coupled receptor B3 isoform X1

UniProtKB/TrEMBL

Q499E3

Related

ENSMUSP00000116759.2, ENSMUST00000146592.8

Conserved Domains (6) summary

smart00303
Location:816 → 867

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:510 → 576

HormR; Domain present in hormone receptors

smart00209
Location:348 → 398

TSP1; Thrombospondin type 1 repeats

cd15251
Location:874 → 1131

7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:594 → 794

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

pfam19188
Location:29 → 203

AGRB_N; Adhesion GPCR B N-terminal region
XM_006495817.5 → XP_006495880.1 adhesion G protein-coupled receptor B3 isoform X2

UniProtKB/TrEMBL

Q499E3

Conserved Domains (5) summary

smart00303
Location:816 → 867

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:510 → 576

HormR; Domain present in hormone receptors

smart00209
Location:348 → 398

TSP1; Thrombospondin type 1 repeats

cd15989
Location:872 → 1164

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:594 → 794

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_036163223.1 → XP_036019116.1 adhesion G protein-coupled receptor B3 isoform X5

UniProtKB/TrEMBL

Q8K0A3

Conserved Domains (3) summary

smart00303
Location:228 → 279

GPS; G-protein-coupled receptor proteolytic site domain

cd15989
Location:284 → 576

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:6 → 206

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_006495818.5 → XP_006495881.1 adhesion G protein-coupled receptor B3 isoform X5

UniProtKB/TrEMBL

Q8K0A3

Conserved Domains (3) summary

smart00303
Location:228 → 279

GPS; G-protein-coupled receptor proteolytic site domain

cd15989
Location:284 → 576

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:6 → 206

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_017319555.3 → XP_017175044.1 adhesion G protein-coupled receptor B3 isoform X4

UniProtKB/TrEMBL

Q68FL1

Conserved Domains (5) summary

smart00303
Location:483 → 534

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:177 → 243

HormR; Domain present in hormone receptors

smart00209
Location:15 → 65

TSP1; Thrombospondin type 1 repeats

cd15989
Location:539 → 831

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:261 → 461

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
XM_036163221.1 → XP_036019114.1 adhesion G protein-coupled receptor B3 isoform X4

UniProtKB/TrEMBL

Q68FL1

Conserved Domains (5) summary

smart00303
Location:483 → 534

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:177 → 243

HormR; Domain present in hormone receptors

smart00209
Location:15 → 65

TSP1; Thrombospondin type 1 repeats

cd15989
Location:539 → 831

7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam16489
Location:261 → 461

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain