Ear2 eosinophil-associated, ribonuclease A family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ear2provided by MGI
Official Full Name: eosinophil-associated, ribonuclease A family, member 2provided by MGI
Primary source: MGI:MGI:108020
See related: Ensembl:ENSMUSG00000072596 AllianceGenome:MGI:108020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ECP; Raf3; EAR-2; ECP 2; EAR-13; Rnase2
Summary: Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Involved in chemotaxis. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 106.3), liver E18 (RPKM 32.3) and 8 other tissues See more
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Genomic context

Location:: 14; 14 C1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (44340111..44340988)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (44102654..44103531)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional activity of four mouse eosinophil associated ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
Title: Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities.
Testing spatial memory and hippocampal long-term potentiation revealed an impairment in APP/PS1 Ear2(-/-) mice, whereas APP/PS1 or Ear2(-/-) mice showed only minor changes.
Title: Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.
this suggests that ECP can activate a canonical Wnt/b-catenin signaling pathway by enhancing the stabilization of b-catenin during cardiomyocyte differentiation.
Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Ear2 ligand binding domain is required for Rasd1 to alleviate Ear2-mediated repression of renin transcription.
Title: Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.
EDN can activate myeloid DCs by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway
Title: Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.
decreased expression of total mEar2 mRNA and protein in lung tissue and a corresponding fivefold drop in ribonuclease activity in BALF in pneumovirus infection of mice
Title: Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo.
was selectively chemotactic for dendritic cells; induced the activation of p42/44 MAPK in DCs
Title: Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D14Mit139 (e-PCR), detects polymorphism
- UniSTS:127244

D14Mit139.2 (e-PCR)
- UniSTS:127245

NoName (e-PCR)
- UniSTS:492884

NoName (e-PCR)
- UniSTS:491405

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eosinophil cationic protein 2

Names: RNase 3-2; eosinophil secondary granule ribonuclease 2; eosinophil-associated ribonuclease 13; eosinophil-associated ribonuclease 2; eosinophil-derived neurotoxin, liver; ribonuclease 3-2; ribonuclease A f3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.