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    Irgq immunity-related GTPase family, Q [ Mus musculus (house mouse) ]

    Gene ID: 210146, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Irgqprovided by MGI
    Official Full Name
    immunity-related GTPase family, Qprovided by MGI
    Primary source
    MGI:MGI:2667176
    See related
    Ensembl:ENSMUSG00000041037 AllianceGenome:MGI:2667176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irgq1; FKSG27
    Summary
    Predicted to enable GTP binding activity. Is expressed in cortical plate. Orthologous to human IRGQ (immunity related GTPase Q). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 18.6), CNS E18 (RPKM 17.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Irgq in Genome Data Viewer
    Location:
    7 A3; 7 11.32 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24230073..24238025)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24530648..24538600)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cell adhesion molecule 4 Neighboring gene zinc finger protein 428 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25315449-25315632 Neighboring gene STARR-seq mESC enhancer starr_18269 Neighboring gene phospholipase A2 inhibitor and LY6/PLAUR domain containing Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. Miyairi I, et al. J Immunol, 2007 Aug 1. PMID 17641048
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    immunity-related GTPase family Q protein
    Names
    immunity-related GTPase family, Q1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153134.3 → NP_694774.3  immunity-related GTPase family Q protein

      See identical proteins and their annotated locations for NP_694774.3

      Status: VALIDATED

      Source sequence(s)
      BC080294, CJ128671
      Consensus CDS
      CCDS20953.1
      UniProtKB/Swiss-Prot
      Q7TNC7, Q8VIM9
      Related
      ENSMUSP00000036699.8, ENSMUST00000049020.9
      Conserved Domains (2) summary
      cd00267
      Location:3 → 29
      ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
      cl21455
      Location:224 → 286
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24230073..24238025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VIM9.1 GenPept UniProtKB/Swiss-Prot:Q8VIM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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