Hdac4 histone deacetylase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdac4provided by MGI
Official Full Name: histone deacetylase 4provided by MGI
Primary source: MGI:MGI:3036234
See related: Ensembl:ENSMUSG00000026313 AllianceGenome:MGI:3036234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HD4; 4932408F19Rik
Summary: Enables several functions, including protein kinase binding activity; protein lysine deacetylase activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of myotube differentiation. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; forelimb; ganglia; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 12.3), ovary adult (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.24 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91856501..92123424, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91928779..92195702, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
Title: Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.
Title: Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.
CX3CL1 represses autophagy via CX3CR1/ CaMKIIdelta/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis.
Title: CX3CL1 represses autophagy via CX3CR1/ CaMKIIδ/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis.
WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
Title: WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.
SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Title: SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Cytoplasmic HDAC4 recovers synaptic function in the 3xTg mouse model of Alzheimer's disease.
Title: Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's disease.
Sex and HDAC4 Differently Affect the Pathophysiology of Amyotrophic Lateral Sclerosis in SOD1-G93A Mice.
Title: Sex and HDAC4 Differently Affect the Pathophysiology of Amyotrophic Lateral Sclerosis in SOD1-G93A Mice.
Kinase signalling in excitatory neurons regulates sleep quantity and depth.
Title: Kinase signalling in excitatory neurons regulates sleep quantity and depth.
KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
Title: KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
Histone deacetylase 4 inhibition ameliorates the social deficits induced by Ephrin-B2 mutation.
Title: Histone deacetylase 4 inhibition ameliorates the social deficits induced by Ephrin-B2 mutation.

Submit: New GeneRIF Correction See all GeneRIFs (120)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (12) 1 citation
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234174 (e-PCR)
- UniSTS:234174

NoName (e-PCR)
- UniSTS:234175

NoName (e-PCR)
- UniSTS:234176

D1Mit365 (e-PCR), detects polymorphism
- UniSTS:128724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables potassium ion binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
contributes_to transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of miRNA transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male mating behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cardiac muscle contraction by calcium ion signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of skeletal muscle fiber development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of skeletal muscle fiber differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to denervation involved in regulation of muscle adaptation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in actomyosin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone deacetylase 4

NP_997108.1

EC 3.5.1.98

XP_006529374.1

EC 3.5.1.98

XP_006529375.1

EC 3.5.1.98

XP_006529376.1

EC 3.5.1.98

XP_006529377.1

EC 3.5.1.98

XP_006529378.1

EC 3.5.1.98

XP_017174965.1

EC 3.5.1.98

XP_017174966.1

EC 3.5.1.98

XP_017174967.1

EC 3.5.1.98

XP_017174968.1

EC 3.5.1.98

XP_017174969.1

EC 3.5.1.98

XP_017174971.1

EC 3.5.1.98

XP_017174975.1

EC 3.5.1.98

XP_017174976.1

EC 3.5.1.98

XP_017174977.1

EC 3.5.1.98

XP_017174987.1

EC 3.5.1.98

XP_017174990.1

EC 3.5.1.98

XP_030108389.1

EC 3.5.1.98

XP_030108391.1

EC 3.5.1.98

XP_030108401.1

EC 3.5.1.98

XP_030108409.1

EC 3.5.1.98

XP_030108410.1

EC 3.5.1.98

XP_030108412.1

EC 3.5.1.98

XP_036019018.1

EC 3.5.1.98

XP_036019024.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207225.2 → NP_997108.1 histone deacetylase 4

See identical proteins and their annotated locations for NP_997108.1

Status: VALIDATED

Source sequence(s)

AC109197, AC163436, BC066052, BY265337

Consensus CDS

CCDS48324.1

UniProtKB/Swiss-Prot

Q3TRZ9, Q3U2J3, Q3V3Y4, Q6NZM9

Related

ENSMUSP00000095249.4, ENSMUST00000097644.9

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:646 → 1049

HDAC4; Histone deacetylase 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

91856501..92123424 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319488.2 → XP_017174977.1 histone deacetylase 4 isoform X7

UniProtKB/Swiss-Prot

Q3TRZ9, Q3U2J3, Q3V3Y4, Q6NZM9

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:646 → 1049

HDAC4; Histone deacetylase 4
XM_017319486.2 → XP_017174975.1 histone deacetylase 4 isoform X2

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:646 → 1054

HDAC4; Histone deacetylase 4
XM_017319487.2 → XP_017174976.1 histone deacetylase 4 isoform X3

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1054

HDAC4; Histone deacetylase 4
XM_017319480.2 → XP_017174969.1 histone deacetylase 4 isoform X1

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1059

HDAC4; Histone deacetylase 4
XM_017319498.2 → XP_017174987.1 histone deacetylase 4 isoform X10

Conserved Domains (1) summary

cd10006
Location:480 → 888

HDAC4; Histone deacetylase 4
XM_030252529.1 → XP_030108389.1 histone deacetylase 4 isoform X1

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1059

HDAC4; Histone deacetylase 4
XM_030252549.1 → XP_030108409.1 histone deacetylase 4 isoform X8

Conserved Domains (2) summary

cd10162
Location:63 → 124

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:624 → 1032

HDAC4; Histone deacetylase 4
XM_030252550.2 → XP_030108410.1 histone deacetylase 4 isoform X9

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:602 → 1010

HDAC4; Histone deacetylase 4
XM_030252541.1 → XP_030108401.1 histone deacetylase 4 isoform X7

UniProtKB/Swiss-Prot

Q3TRZ9, Q3U2J3, Q3V3Y4, Q6NZM9

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:646 → 1049

HDAC4; Histone deacetylase 4
XM_030252531.1 → XP_030108391.1 histone deacetylase 4 isoform X2

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:646 → 1054

HDAC4; Histone deacetylase 4
XM_017319482.2 → XP_017174971.1 histone deacetylase 4 isoform X3

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1054

HDAC4; Histone deacetylase 4
XM_006529315.3 → XP_006529378.1 histone deacetylase 4 isoform X1

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1059

HDAC4; Histone deacetylase 4
XM_017319479.1 → XP_017174968.1 histone deacetylase 4 isoform X4

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:607 → 1015

HDAC4; Histone deacetylase 4
XM_017319477.1 → XP_017174966.1 histone deacetylase 4 isoform X2

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:646 → 1054

HDAC4; Histone deacetylase 4
XM_017319478.1 → XP_017174967.1 histone deacetylase 4 isoform X3

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1054

HDAC4; Histone deacetylase 4
XM_017319476.1 → XP_017174965.1 histone deacetylase 4 isoform X1

Conserved Domains (2) summary

cd10162
Location:90 → 151

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:651 → 1059

HDAC4; Histone deacetylase 4
XM_006529312.2 → XP_006529375.1 histone deacetylase 4 isoform X8

See identical proteins and their annotated locations for XP_006529375.1

Conserved Domains (2) summary

cd10162
Location:63 → 124

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:624 → 1032

HDAC4; Histone deacetylase 4
XM_017319501.2 → XP_017174990.1 histone deacetylase 4 isoform X11

Conserved Domains (1) summary

cd10006
Location:480 → 883

HDAC4; Histone deacetylase 4
XM_030252552.1 → XP_030108412.1 histone deacetylase 4 isoform X10

Conserved Domains (1) summary

cd10006
Location:480 → 888

HDAC4; Histone deacetylase 4
XM_006529313.2 → XP_006529376.1 histone deacetylase 4 isoform X8

See identical proteins and their annotated locations for XP_006529376.1

Conserved Domains (2) summary

cd10162
Location:63 → 124

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:624 → 1032

HDAC4; Histone deacetylase 4
XM_036163125.1 → XP_036019018.1 histone deacetylase 4 isoform X6

Conserved Domains (2) summary

cd10162
Location:99 → 160

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:660 → 1068

HDAC4; Histone deacetylase 4
XM_006529314.4 → XP_006529377.1 histone deacetylase 4 isoform X8

See identical proteins and their annotated locations for XP_006529377.1

Conserved Domains (2) summary

cd10162
Location:63 → 124

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:624 → 1032

HDAC4; Histone deacetylase 4
XM_036163131.1 → XP_036019024.1 histone deacetylase 4 isoform X8

Conserved Domains (2) summary

cd10162
Location:63 → 124

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:624 → 1032

HDAC4; Histone deacetylase 4
XM_006529311.4 → XP_006529374.1 histone deacetylase 4 isoform X5

Conserved Domains (2) summary

cd10162
Location:104 → 165

ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase

cd10006
Location:665 → 1073

HDAC4; Histone deacetylase 4