CDC6 cell division cycle 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC6provided by HGNC
Official Full Name: cell division cycle 6provided by HGNC
Primary source: HGNC:HGNC:1744
See related: Ensembl:ENSG00000094804 MIM:602627; AllianceGenome:HGNC:1744
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDC18L; HsCDC6; MGORS5; HsCDC18
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (40287879..40304657)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (41151103..41168161)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (38444131..38460909)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses.
Title: CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses.
Role of TOP2A and CDC6 in liver cancer.
Title: Role of TOP2A and CDC6 in liver cancer.
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
Title: CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.
Title: FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.
The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
Title: The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells.
Title: MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells.
UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications.
Title: UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications.
CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme.
Title: CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme.
Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
Title: Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.
Title: Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Meier-Gorlin syndrome 5 MedGen: C3151126 OMIM: 613805 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-U77949 (e-PCR)
- UniSTS:63534

PMC109252P1 (e-PCR)
- UniSTS:270158

CDC6_1451 (e-PCR)
- UniSTS:277082

CDC6_v482 (e-PCR)
- UniSTS:277082

RH70424 (e-PCR)
- UniSTS:77254

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotide binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication checkpoint signaling	TAS Traceable Author Statement more info	PubMed
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to angiotensin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vasopressin	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA replication	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of chromosome segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in traversing start control point of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cell division control protein 6 homolog

Names: CDC6 cell division cycle 6 homolog; CDC6-related protein; cdc18-related protein; cell division cycle 6 homolog; p62(cdc6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028240.2 RefSeqGene

Range

5001..21779

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1257

mRNA and Protein(s)

NM_001254.4 → NP_001245.1 cell division control protein 6 homolog

See identical proteins and their annotated locations for NP_001245.1

Status: REVIEWED

Source sequence(s)

AC080112, AK313620, BC025232

Consensus CDS

CCDS11365.1

UniProtKB/Swiss-Prot

Q8TB30, Q99741

UniProtKB/TrEMBL

B2R935

Related

ENSP00000209728.4, ENST00000209728.9

Conserved Domains (3) summary

smart01074
Location:465 → 545

Cdc6_C; CDC6, C terminal

COG1474
Location:168 → 547

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13191
Location:171 → 314

AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

40287879..40304657

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525542.2 → XP_011523844.1 cell division control protein 6 homolog isoform X1

See identical proteins and their annotated locations for XP_011523844.1

UniProtKB/TrEMBL

B2R935

Conserved Domains (3) summary

smart01074
Location:505 → 585

Cdc6_C; CDC6, C terminal

COG1474
Location:168 → 587

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13191
Location:171 → 314

AAA_16; AAA ATPase domain
XM_047437207.1 → XP_047293163.1 cell division control protein 6 homolog isoform X2

UniProtKB/Swiss-Prot

Q8TB30, Q99741
XM_011525541.3 → XP_011523843.1 cell division control protein 6 homolog isoform X1

See identical proteins and their annotated locations for XP_011523843.1

UniProtKB/TrEMBL

B2R935

Conserved Domains (3) summary

smart01074
Location:505 → 585

Cdc6_C; CDC6, C terminal

COG1474
Location:168 → 587

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13191
Location:171 → 314

AAA_16; AAA ATPase domain

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

41151103..41168161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054318058.1 → XP_054174033.1 cell division control protein 6 homolog isoform X1
XM_054318059.1 → XP_054174034.1 cell division control protein 6 homolog isoform X2
XM_054318057.1 → XP_054174032.1 cell division control protein 6 homolog isoform X1