Taar6 trace amine-associated receptor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taar6provided by MGI
Official Full Name: trace amine-associated receptor 6provided by MGI
Primary source: MGI:MGI:2685074
See related: Ensembl:ENSMUSG00000045111 AllianceGenome:MGI:2685074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm228; taR-6
Summary: Enables trace-amine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; ileum; and nose. Orthologous to human TAAR6 (trace amine associated receptor 6). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.4 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23860507..23861544, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23984609..23985646, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.
Title: Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.
Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
Title: A second class of chemosensory receptors in the olfactory epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

Taar6 (e-PCR), detects polymorphism
- UniSTS:516840

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: trace amine-associated receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010828.1 → NP_001010828.1 trace amine-associated receptor 6

See identical proteins and their annotated locations for NP_001010828.1

Status: VALIDATED

Source sequence(s)

AY702330

Consensus CDS

CCDS23739.1

UniProtKB/Swiss-Prot

Q5QD13

Related

ENSMUSP00000097603.2, ENSMUST00000057080.4

Conserved Domains (2) summary

pfam00001
Location:49 → 311

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:43 → 271

7tm_4; Olfactory receptor