U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PCM1 pericentriolar material 1 [ Homo sapiens (human) ]

    Gene ID: 5108, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PCM1provided by HGNC
    Official Full Name
    pericentriolar material 1provided by HGNC
    Primary source
    HGNC:HGNC:8727
    See related
    Ensembl:ENSG00000078674 MIM:600299; AllianceGenome:HGNC:8727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTC4; RET/PCM-1
    Summary
    The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PCM1 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17922988..18029948)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (18190478..18297432)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17780497..17887457)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene fibrinogen like 1 Neighboring gene endogenous retrovirus group K member 25 Env polyprotein-like Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:17769002-17769792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17769793-17770581 Neighboring gene Sharpr-MPRA regulatory region 2266 Neighboring gene uncharacterized LOC124901867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27048 Neighboring gene Sharpr-MPRA regulatory region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27050 Neighboring gene uncharacterized LOC124901894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:17911125-17911698 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17942063-17942598 Neighboring gene ASAH1 antisense RNA 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mapping of the human autoantigen pericentriolar material 1 (PCM1) gene to chromosome 8p21.3-p22. Ohata H, et al. Genomics, 1994 Nov 15. PMID 7698772
    2. Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Gurling HM, et al. Arch Gen Psychiatry, 2006 Aug. PMID 16894060, Free PMC Article
    3. Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. Srsen V, et al. J Cell Biol, 2006 Aug 28. PMID 16943179, Free PMC Article
    4. LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM1 in neurosyphilis. Liu WN, et al. Epigenomics, 2021 Aug. PMID 34382410
    5. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. Datta SR, et al. Mol Psychiatry, 2010 Jun. PMID 19048012

    See all (195) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA-ENST00000421645 promotes T cells to secrete IFN-gamma by sponging PCM1 in neurosyphilis.
      Title: LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM1 in neurosyphilis.
    2. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
      Title: PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
    3. SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.
      Title: SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.
    4. study reveals that USP9X is a constituent of centriolar satellites and functions to maintain centriolar satellite integrity by stabilizing PCM1.
      Title: Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
    5. detecting PDGFRA, PDGFRB, FGFR1 and PCM1-JAK2 rearrangements is a prerequisite for up-to-date WHO classification, and an essential step in the differential diagnosis of neoplasms with eosinophilia.
      Title: Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.
    6. In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.
      Title: Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.
    7. Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
      Title: The X-linked deubiquitinase USP9X is an integral component of centrosome.
    8. a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer
      Title: Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer.
    9. no association between the PCM1 gene and schizophrenia in a Japanese population
      Title: Four polymorphisms of the pericentriolar material 1 (PCM1) gene are not associated with schizophrenia in a Japanese population.
    10. Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
      Title: Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interkinetic nuclear migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein-containing complex localization to centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein complex stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in social behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    NOT located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in pericentriolar material ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    pericentriolar material 1 protein
    Names
    PCM-1
    hPCM-1
    pericentriolar material 1, PCM1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027690.2 RefSeqGene

      Range
      5002..111962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001315507.2 → NP_001302436.2  pericentriolar material 1 protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS83256.1
      UniProtKB/TrEMBL
      A0A5H1ZRS1, B9EIS5
      Related
      ENSP00000431099.1, ENST00000519253.5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 1990
      PCM1_C; Pericentriolar material 1 C-terminus

    2. NM_001315508.2 → NP_001302437.2  pericentriolar material 1 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame segments compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS83255.1
      UniProtKB/TrEMBL
      A0A4W8VX11, A2RUU9
      Related
      ENSP00000430521.1, ENST00000524226.5
      Conserved Domains (1) summary
      pfam15717
      Location:1318 → 1834
      PCM1_C; Pericentriolar material 1 C-terminus

    3. NM_001352632.2 → NP_001339561.2  pericentriolar material 1 protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1411 → 2041
      PCM1_C; Pericentriolar material 1 C-terminus

    4. NM_001352633.2 → NP_001339562.2  pericentriolar material 1 protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1418 → 2036
      PCM1_C; Pericentriolar material 1 C-terminus

    5. NM_001352634.2 → NP_001339563.2  pericentriolar material 1 protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 2002
      PCM1_C; Pericentriolar material 1 C-terminus

    6. NM_001352635.2 → NP_001339564.2  pericentriolar material 1 protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1373 → 1991
      PCM1_C; Pericentriolar material 1 C-terminus

    7. NM_001352636.2 → NP_001339565.2  pericentriolar material 1 protein isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1357 → 1983
      PCM1_C; Pericentriolar material 1 C-terminus

    8. NM_001352637.2 → NP_001339566.2  pericentriolar material 1 protein isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1356 → 1982
      PCM1_C; Pericentriolar material 1 C-terminus

    9. NM_001352638.2 → NP_001339567.2  pericentriolar material 1 protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1356 → 1974
      PCM1_C; Pericentriolar material 1 C-terminus

    10. NM_001352639.2 → NP_001339568.2  pericentriolar material 1 protein isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1947
      PCM1_C; Pericentriolar material 1 C-terminus

    11. NM_001352640.2 → NP_001339569.2  pericentriolar material 1 protein isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1318 → 1944
      PCM1_C; Pericentriolar material 1 C-terminus

    12. NM_001352641.2 → NP_001339570.2  pericentriolar material 1 protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1939
      PCM1_C; Pericentriolar material 1 C-terminus

    13. NM_001352642.2 → NP_001339571.2  pericentriolar material 1 protein isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      A2RUU9
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1833
      PCM1_C; Pericentriolar material 1 C-terminus

    14. NM_001352643.2 → NP_001339572.2  pericentriolar material 1 protein isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1411 → 1509
      PCM1_C; Pericentriolar material 1 C-terminus

    15. NM_001352644.2 → NP_001339573.2  pericentriolar material 1 protein isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform 16.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1943
      PCM1_C; Pericentriolar material 1 C-terminus

    16. NM_001352645.2 → NP_001339574.2  pericentriolar material 1 protein isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform 16.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1943
      PCM1_C; Pericentriolar material 1 C-terminus

    17. NM_001352646.2 → NP_001339575.2  pericentriolar material 1 protein isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 19, encodes isoform 17.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1935
      PCM1_C; Pericentriolar material 1 C-terminus

    18. NM_001352647.2 → NP_001339576.2  pericentriolar material 1 protein isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variant 18, encodes isoform 17.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1935
      PCM1_C; Pericentriolar material 1 C-terminus

    19. NM_001352648.2 → NP_001339577.2  pericentriolar material 1 protein isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variant 21, encodes isoform 18.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1318 → 1936
      PCM1_C; Pericentriolar material 1 C-terminus

    20. NM_001352649.2 → NP_001339578.2  pericentriolar material 1 protein isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 20, encodes isoform 18.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      B9EIS5
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1318 → 1936
      PCM1_C; Pericentriolar material 1 C-terminus

    21. NM_001352650.2 → NP_001339579.2  pericentriolar material 1 protein isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variant 23, encodes isoform 19.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1411 → 2037
      PCM1_C; Pericentriolar material 1 C-terminus

    22. NM_001352651.2 → NP_001339580.2  pericentriolar material 1 protein isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variant 22, encodes isoform 19.
      Source sequence(s)
      AC087273, AC087625
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15717
      Location:1411 → 2037
      PCM1_C; Pericentriolar material 1 C-terminus

    23. NM_001352652.2 → NP_001339581.2  pericentriolar material 1 protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS47812.1
      UniProtKB/Swiss-Prot
      A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 1998
      PCM1_C; Pericentriolar material 1 C-terminus

    24. NM_001352653.2 → NP_001339582.2  pericentriolar material 1 protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS47812.1
      UniProtKB/Swiss-Prot
      A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
      UniProtKB/TrEMBL
      H0YBA1
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 1998
      PCM1_C; Pericentriolar material 1 C-terminus

    25. NM_001352654.2 → NP_001339583.2  pericentriolar material 1 protein isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 27 and 28, encodes isoform 21.
      Source sequence(s)
      AC087273, AC087625
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 447
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1415
      PCM1_C; Pericentriolar material 1 C-terminus

    26. NM_001352655.2 → NP_001339584.2  pericentriolar material 1 protein isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 26 and 28, encodes isoform 21.
      Source sequence(s)
      AC087273, AC087625
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 447
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1415
      PCM1_C; Pericentriolar material 1 C-terminus

    27. NM_001352656.2 → NP_001339585.2  pericentriolar material 1 protein isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 26 and 27, encodes isoform 21.
      Source sequence(s)
      AC087273, AC087625
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 447
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1317 → 1415
      PCM1_C; Pericentriolar material 1 C-terminus

    28. NM_001352657.2 → NP_001339586.2  pericentriolar material 1 protein isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variant 30, encodes isoform 22.
      Source sequence(s)
      AC087273, AC087625
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 1470
      PCM1_C; Pericentriolar material 1 C-terminus

    29. NM_001352658.2 → NP_001339587.2  pericentriolar material 1 protein isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variant 29, encodes isoform 22.
      Source sequence(s)
      AC087273, AC087625
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 1470
      PCM1_C; Pericentriolar material 1 C-terminus

    30. NM_001352659.2 → NP_001339588.2  pericentriolar material 1 protein isoform 23

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variant 32, encodes isoform 23.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS87582.1
      UniProtKB/TrEMBL
      E9PGW9
      Related
      ENSP00000428123.1, ENST00000518537.5
      Conserved Domains (1) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    31. NM_001352660.2 → NP_001339589.2  pericentriolar material 1 protein isoform 23

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variant 31, encodes isoform 23.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS87582.1
      UniProtKB/TrEMBL
      E9PGW9
      Conserved Domains (1) summary
      COG1196
      Location:226 → 463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    32. NM_006197.4 → NP_006188.4  pericentriolar material 1 protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 24, and 25 encode isoform 1.
      Source sequence(s)
      AC087273, AC087625
      Consensus CDS
      CCDS47812.1
      UniProtKB/Swiss-Prot
      A6NNN6, B4DYD5, E7ETA6, E7EV56, Q15154, Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2
      UniProtKB/TrEMBL
      H0YBA1
      Related
      ENSP00000327077.8, ENST00000325083.13
      Conserved Domains (2) summary
      TIGR02302
      Location:231 → 450
      aProt_lowcomp; TIGR02302 family protein
      pfam15717
      Location:1372 → 1998
      PCM1_C; Pericentriolar material 1 C-terminus

    RNA

    1. NR_148032.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087273, AC087625

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      17922988..18029948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      18190478..18297432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15154.6 GenPept UniProtKB/Swiss-Prot:Q15154

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous