NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029367.1 RefSeqGene
- Range
-
5028..46742
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001204171.2 → NP_001191100.1 protein Mdm4 isoform 2
See identical proteins and their annotated locations for NP_001191100.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as MDM4-A or HDMX-A) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment in the 3' coding region compared to isoform 1.
- Source sequence(s)
-
AB209383, AK097188, AL512306, BC105106, BP247507, BP334671, BX108199
- Consensus CDS
-
CCDS55674.1
- UniProtKB/Swiss-Prot
-
O15151
- UniProtKB/TrEMBL
-
Q59FS6
- Related
- ENSP00000396840.2, ENST00000454264.6
- Conserved Domains (2) summary
-
- pfam00641
Location:250 → 279
- zf-RanBP; Zn-finger in Ran binding protein and others
- pfam13920
Location:385 → 432
- zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
-
NM_001204172.2 → NP_001191101.1 protein Mdm4 isoform 3
See identical proteins and their annotated locations for NP_001191101.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as MDM4-211 or HDMX211) is missing 8 consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. However, it maintains the reading frame, and encodes a very short isoform (3) that lacks the N-terminal p53 binding domain, but retains the ring finger domain at the C-terminus. This isoform has been shown to bind and stabilize oncoprotein HDM2, and also indirectly stabilize p53 protein by counteracting its degradation by HDM2. Screening of lung cancer biopsies shows the presence of this isoform in samples that overexpress HDM2 protein, supporting a pathologic role for this protein (PMID:16266988).
- Source sequence(s)
-
AB209383, AK097188, AL512306, AY923176, BP247507, BP334671, BX108199
- Consensus CDS
-
CCDS55675.1
- UniProtKB/Swiss-Prot
-
O15151
- UniProtKB/TrEMBL
-
Q59FS6
- Related
- ENSP00000356151.3, ENST00000367183.7
- Conserved Domains (1) summary
-
- pfam13920
Location:109 → 156
- zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
-
NM_001278516.2 → NP_001265445.1 protein Mdm4 isoform 4
See identical proteins and their annotated locations for NP_001265445.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as MDM4-S, HDMX-S, or HDMX-E) lacks an internal coding exon compared to variant 1. The resulting isoform (4) has a much shorter and alternate C-terminus compared to isoform 1. Annotation of this protein causes this transcript to be a candidate for nonsense-mediated mRNA decay (NMD); however, this protein was shown in PMID: 10075736 to be biologically valid.
- Source sequence(s)
-
AK310903, AL512306, BC067299, BX108199
- Consensus CDS
-
CCDS60396.1
- UniProtKB/TrEMBL
- Q58HK1, Q68DC0
- Related
- ENSP00000375811.2, ENST00000391947.6
- Conserved Domains (1) summary
-
- cl02489
Location:51 → 76
- SWIB; SWIB/MDM2 domain
-
NM_001278517.2 → NP_001265446.1 protein Mdm4 isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (5, also known as MDM4-G or HDMX-G) lacks three consecutive exons and part of the fourth compared to variant 1. The resulting isoform (5) has the same N- and C-termini but lacks a large internal segment compared to isoform 1.
- Source sequence(s)
-
AL512306, BC067299, BX108199
- Consensus CDS
-
CCDS73009.1
- UniProtKB/TrEMBL
-
A0A087WZ58
- Related
- ENSP00000482388.1, ENST00000614459.4
- Conserved Domains (2) summary
-
- pfam00641
Location:202 → 231
- zf-RanBP; Zn-finger in Ran binding protein and others
- pfam13920
Location:337 → 384
- zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
-
NM_001278518.2 → NP_001265447.1 protein Mdm4 isoform 6
Status: REVIEWED
- Description
- Transcript Variant: This variant (6, also known as MDM4-ALT1, XALT1, or HDMX-ALT1) lacks four consecutive exons compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1. Annotation of this protein causes this transcript to be a candidate for nonsense-mediated mRNA decay (NMD); however, since transcript variant 4 escapes NMD, it is likely that isoform 6 is also biologically valid.
- Source sequence(s)
-
AL512306, BC067299, BX108199
- Consensus CDS
-
CCDS73007.1
- UniProtKB/TrEMBL
- A0A087WUE3, B4E122
- Related
- ENSP00000478581.1, ENST00000616250.4
- Conserved Domains (1) summary
-
- cl02489
Location:26 → 76
- SWIB; SWIB/MDM2 domain
-
NM_001278519.2 → NP_001265448.1 protein Mdm4 isoform 7
Status: REVIEWED
- Description
- Transcript Variant: This variant (7, also known as MDM4-ALT2, XALT2, or HDMX-ALT2) lacks six consecutive exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but lacks a large internal segment compared to isoform 1.
- Source sequence(s)
-
AL512306, BC067299, BX108199
- Consensus CDS
-
CCDS73008.1
- UniProtKB/TrEMBL
- A0A087WTR9, Q59FS6
- Related
- ENSP00000478080.1, ENST00000612738.4
- Conserved Domains (2) summary
-
- pfam00641
Location:77 → 106
- zf-RanBP; Zn-finger in Ran binding protein and others
- pfam13920
Location:212 → 259
- zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
-
NM_002393.5 → NP_002384.2 protein Mdm4 isoform 1
See identical proteins and their annotated locations for NP_002384.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as MDM4-FL or HDMX) represents the predominant transcript, and encodes the longest isoform (1).
- Source sequence(s)
-
AB209383, AK097188, AL512306, BC067299, BP247507, BP334671, BX108199
- Consensus CDS
-
CCDS1447.1
- UniProtKB/Swiss-Prot
- O15151, Q2M2Y2, Q32SL2, Q6GS18, Q8IV83
- Related
- ENSP00000356150.3, ENST00000367182.8
- Conserved Domains (2) summary
-
- pfam00641
Location:300 → 329
- zf-RanBP; Zn-finger in Ran binding protein and others
- cd16784
Location:432 → 490
- mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
204516406..204558120
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024447114.2 → XP_024302882.1 protein Mdm4 isoform X3
- UniProtKB/Swiss-Prot
- O15151, Q2M2Y2, Q32SL2, Q6GS18, Q8IV83
- Conserved Domains (2) summary
-
- pfam00641
Location:300 → 329
- zf-RanBP; Zn-finger in Ran binding protein and others
- cd16784
Location:432 → 490
- mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
-
XM_047420951.1 → XP_047276907.1 protein Mdm4 isoform X5
-
XM_024447115.2 → XP_024302883.1 protein Mdm4 isoform X3
- UniProtKB/Swiss-Prot
- O15151, Q2M2Y2, Q32SL2, Q6GS18, Q8IV83
- Conserved Domains (2) summary
-
- pfam00641
Location:300 → 329
- zf-RanBP; Zn-finger in Ran binding protein and others
- cd16784
Location:432 → 490
- mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
-
XM_017001311.2 → XP_016856800.1 protein Mdm4 isoform X1
-
XM_017001312.2 → XP_016856801.1 protein Mdm4 isoform X2
-
XM_017001313.2 → XP_016856802.1 protein Mdm4 isoform X4
-
XM_047420955.1 → XP_047276911.1 protein Mdm4 isoform X7
-
XM_047420961.1 → XP_047276917.1 protein Mdm4 isoform X8
-
XM_047420952.1 → XP_047276908.1 protein Mdm4 isoform X6
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
203780802..203822528
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054336650.1 → XP_054192625.1 protein Mdm4 isoform X7
-
XM_054336651.1 → XP_054192626.1 protein Mdm4 isoform X8