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    SNHG29 small nucleolar RNA host gene 29 [ Homo sapiens (human) ]

    Gene ID: 125144, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SNHG29provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 29provided by HGNC
    Primary source
    HGNC:HGNC:28619
    See related
    Ensembl:ENSG00000175061 AllianceGenome:HGNC:28619
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACIL; TSAP19; C17orf45; NCRNA00188; FAM211A-AS1; LRRC75A-AS1; C17orf76-AS1
    Summary
    Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 110.6), thyroid (RPKM 105.4) and 25 other tissues See more
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    Genomic context

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    See SNHG29 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16438987..16470648)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16341290..16372939)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16342301..16373962)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16329088-16329588 Neighboring gene transient receptor potential cation channel subfamily V member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16339567-16340199 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16340803-16341704 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16341705-16342604 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16342605-16343506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16347109-16348008 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16351973-16352474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16352475-16352974 Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16359695-16360196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16360197-16360696 Neighboring gene Sharpr-MPRA regulatory regions 7543 and 3494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16369025-16369816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16379787-16380698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16380699-16381609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16386369-16387185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16387442-16388368 Neighboring gene uncharacterized LOC124903936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16389294-16390219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16390220-16391144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:16400945-16401445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:16419598-16420797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11767 Neighboring gene uncharacterized LOC124903940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway. Feng X, et al. Med Oncol, 2024 Jan 22. PMID 38252204
    2. A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development. Liu S, et al. Leukemia, 2023 Jul. PMID 37157016
    3. LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma. Pang Q, et al. Cancer Biol Ther, 2020 Nov 1. PMID 33131397, Free PMC Article
    4. Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. Jiang J, et al. Placenta, 2021 Jan 1. PMID 33080448
    5. ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance. Luo R, et al. Cell Insight, 2024 Oct. PMID 39148723, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses.
      Title: Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses.
    2. Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway.
      Title: Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway.
    3. A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development.
      Title: A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development.
    4. LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression.
      Title: LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression.
    5. Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation.
      Title: Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation.
    6. Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
      Title: Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
    7. LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma.
      Title: LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma.
    8. Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC.
      Title: Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC.
    9. LRRC75A-AS1 might serve as an anti-oncogene for colorectal cancer tumorigenesis and advancement.
      Title: Long noncoding RNA LRRC75A-AS1 inhibits cell proliferation and migration in colorectal carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ATR and Chk1 interacting lncRNA
    • C17orf76 antisense RNA 1 (non-protein coding)
    • FAM211A antisense RNA 1
    • LRRC75A antisense RNA 1

    Clone Names

    • FLJ25777, MGC40157

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027158.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment and two exons, compared to variant 6.
      Source sequence(s)
      AC093484, CN297624
      Related
      ENST00000580180.7

    2. NR_027159.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, BC027986, CF126952
      Related
      ENST00000655540.2

    3. NR_027160.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, BC027986
      Related
      ENST00000660462.2

    4. NR_027161.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, BC027986, BQ954204
      Related
      ENST00000581913.5

    5. NR_027162.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents the longest transcript.
      Source sequence(s)
      AC093484, AK307982

    6. NR_027163.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an internal segment in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, BU599615
      Related
      ENST00000660020.2

    7. NR_027164.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two internal segments in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, CB150672
      Related
      ENST00000667979.3

    8. NR_027165.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two internal segments in the 5' region and an exon in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, BP870476
      Related
      ENST00000666215.3

    9. NR_027166.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an internal segment and an exon in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, CD050014
      Related
      ENST00000688805.2

    10. NR_027167.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks two internal segments in the 5' region and an exon in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, AK309961
      Related
      ENST00000483140.8

    11. NR_027168.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) lacks an internal segment in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, BU506593
      Related
      ENST00000487066.7

    12. NR_027169.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) lacks an internal segment in the 5' region and an exon in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, BP353162
      Related
      ENST00000654778.2

    13. NR_027170.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) lacks two internal segments in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484
      Related
      ENST00000481898.6

    14. NR_027171.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) lacks an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
      Source sequence(s)
      AC093484, BC027986, DA494627, DA793334

    15. NR_027172.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
      Source sequence(s)
      AC127540, DA193585

    16. NR_027173.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
      Source sequence(s)
      AC093484, DA793334, DA857697

    17. NR_027174.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
      Source sequence(s)
      AC093484, DA793334, DA802938

    18. NR_027175.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
      Source sequence(s)
      AC093484, DA485648

    19. NR_027176.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) lacks an internal segment and an exon in the 5' region, lacks two exons in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
      Source sequence(s)
      AC093484, AK308482, DA793334

    20. NR_027177.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
      Source sequence(s)
      AC093484, DA383448, DA793334

    21. NR_027178.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
      Source sequence(s)
      AC093484, DA131201, DA793334

    22. NR_027179.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23) lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, DA867958, DW409012

    23. NR_027667.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an internal segment in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, AK307982, BC027986
      Related
      ENST00000475953.6

    24. NR_045021.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24) lacks an internal segment and an exon in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, AK098643, CD389053
      Related
      ENST00000582911.6

    25. NR_045022.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25) lacks two internal segments and has an alternate segment in the 5' region, compared to variant 6.
      Source sequence(s)
      AC093484, DA440445
      Related
      ENST00000584926.6

    26. NR_045023.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
      Source sequence(s)
      AC093484, AC127540, DA769571

    27. NR_045024.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27) lacks an exon in the 5' region and lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, DB258221

    28. NR_045025.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28) lacks an internal segment and an exon in the 5' region and lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, DA793334

    29. NR_045026.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29) lacks an internal segment in the 5' region and lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, DA867958
      Related
      ENST00000778464.1

    30. NR_045027.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30) lacks an exon in the 5' region and an exon in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, BU165462
      Related
      ENST00000470491.8

    31. NR_045028.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31) lacks an internal segment in the 5' region and lacks an exon in the 3' region, compared to variant 6.
      Source sequence(s)
      AC093484, BI333700

    32. NR_045029.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (32) lacks an internal segment and an exon in the 5' region and has an alternate segement, compared to variant 6.
      Source sequence(s)
      AC093484, BQ070126
      Related
      ENST00000477249.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      16438987..16470648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      16341290..16372939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152350.3: Suppressed sequence

      Description
      NM_152350.3: This RefSeq was permanently suppressed because the gene is not considered to be protein-coding.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials