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    NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

    Gene ID: 10135, updated on 14-Nov-2024

    Summary

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    Official Symbol
    NAMPTprovided by HGNC
    Official Full Name
    nicotinamide phosphoribosyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:30092
    See related
    Ensembl:ENSG00000105835 MIM:608764; AllianceGenome:HGNC:30092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
    Summary
    This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NAMPT in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (106248298..106285888, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (107563712..107602631, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888744..105925429, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901719 Neighboring gene RNA, U6 small nuclear 392, pseudogene Neighboring gene MPRA-validated peak6672 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:105900446-105900972 Neighboring gene NANOG hESC enhancer GRCh37_chr7:105900973-105901497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18533 Neighboring gene NAMPT antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18534 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:105960332-105961531 Neighboring gene LARP1B pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:105986583-105987782 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:106014918-106015131 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:106041193-106041886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:106065201-106066400 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:106089346-106090545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:106206739-106207704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:106207705-106208670 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:106208671-106209636 Neighboring gene uncharacterized CTB-30L5.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway. Feng J, et al. Biomed Res Int, 2016. PMID 28097126, Free PMC Article
    2. Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner. Sanokawa-Akakura R, et al. PLoS One, 2016. PMID 27732642, Free PMC Article
    3. Circulating visfatin level is associated with hepatocellular carcinoma in chronic hepatitis B or C virus infection. Tsai IT, et al. Cytokine, 2017 Feb. PMID 27770715
    4. Genetic variant in visfatin gene promoter contributes to reduced risk of hepatocellular carcinoma in a Chinese population. Wu Z, et al. Oncotarget, 2016 Nov 22. PMID 27792999, Free PMC Article
    5. Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly. Olarescu NC, et al. J Clin Endocrinol Metab, 2012 Apr. PMID 22319029

    See all (661) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between visfatin and periodontitis: a systematic review and meta-analysis.
      Title: Association between visfatin and periodontitis: a systematic review and meta-analysis.
    2. [Mechanism and Clinical Significance of NAMPT in Multiple Myeloma].
      Title: [Mechanism and Clinical Significance of NAMPT in Multiple Myeloma].
    3. NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
      Title: NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
    4. Fibroblast growth factor-21 and Visfatin as potential predictors for metabolic risk factors in obese children.
      Title: Fibroblast growth factor-21 and Visfatin as potential predictors for metabolic risk factors in obese children.
    5. Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population: a case control study.
      Title: Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population: a case control study.
    6. Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus.
      Title: Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus.
    7. The importance of low visfatin values in osteoid osteoma patient: a prospective study.
      Title: The importance of low visfatin values in osteoid osteoma patient: a prospective study.
    8. The cytokine trio - visfatin, placental growth factor and fractalkine - and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA).
      Title: The cytokine trio - visfatin, placental growth factor and fractalkine - and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA).
    9. The Potential Role of Visfatin in Mediating Vascular Dysfunction and Hypertension.
      Title: The Potential Role of Visfatin in Mediating Vascular Dysfunction and Hypertension.
    10. Clock genes regulate skeletal muscle energy metabolism through NAMPT/NAD[+]/SIRT1 following heavy-load exercise.
      Title: Clock genes regulate skeletal muscle energy metabolism through NAMPT/NAD(+)/SIRT1 following heavy-load exercise.
    Submit: New GeneRIF Correction See all GeneRIFs (543)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
    tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
    tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
    tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117256, DKFZp666B131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nicotinamide phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide phosphoribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in adipose tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide phosphoribosyltransferase
    Names
    NAmPRTase
    pre-B cell-enhancing factor
    pre-B-cell colony-enhancing factor 1
    NP_005737.1
    XP_047275655.1
    XP_047275656.1
    XP_054212959.1
    XP_054212960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005746.3 → NP_005737.1  nicotinamide phosphoribosyltransferase precursor

      See identical proteins and their annotated locations for NP_005737.1

      Status: REVIEWED

      Source sequence(s)
      AC007032, AI299587, BC106046, U02020
      Consensus CDS
      CCDS5737.1
      UniProtKB/Swiss-Prot
      A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
      UniProtKB/TrEMBL
      A0A7P0T895
      Related
      ENSP00000222553.3, ENST00000222553.8
      Conserved Domains (1) summary
      cd01569
      Location:12 → 428
      PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      106248298..106285888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419699.1 → XP_047275655.1  nicotinamide phosphoribosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
      Related
      ENSP00000390591.2, ENST00000424768.2

    2. XM_047419700.1 → XP_047275656.1  nicotinamide phosphoribosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A7P0T941
      Related
      ENSP00000505390.1, ENST00000681391.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      107563712..107602631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356984.1 → XP_054212959.1  nicotinamide phosphoribosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95

    2. XM_054356985.1 → XP_054212960.1  nicotinamide phosphoribosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A7P0T941

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182790.1: Suppressed sequence

      Description
      NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43490.1 GenPept UniProtKB/Swiss-Prot:P43490

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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