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    Pigs phosphatidylinositol glycan anchor biosynthesis, class S [ Mus musculus (house mouse) ]

    Gene ID: 276846, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pigsprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Sprovided by MGI
    Primary source
    MGI:MGI:2687325
    See related
    Ensembl:ENSMUSG00000041958 AllianceGenome:MGI:2687325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm393; Gm689
    Summary
    Involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 76.5), ovary adult (RPKM 51.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pigs in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78219272..78233602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78328422..78342776)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene sperm associated antigen 5 Neighboring gene STARR-positive B cell enhancer ABC_E906 Neighboring gene aldolase C, fructose-bisphosphate Neighboring gene unc-119 lipid binding chaperone Neighboring gene STARR-positive B cell enhancer mm9_chr11:78173491-78173792 Neighboring gene forkhead box N1 Neighboring gene predicted gene, 30367

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. Ohishi K, et al. EMBO J, 2001 Aug 1. PMID 11483512, Free PMC Article
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI transamidase component PIG-S
    Names
    phosphatidylinositol glycan, class S homolog
    phosphatidylinositol-glycan biosynthesis class S protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418218.1 → NP_001405147.1  GPI transamidase component PIG-S isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591070
      UniProtKB/TrEMBL
      Q3U643, Q3V3K6

    2. NM_201406.2 → NP_958808.1  GPI transamidase component PIG-S isoform 1

      See identical proteins and their annotated locations for NP_958808.1

      Status: VALIDATED

      Source sequence(s)
      AL591070
      Consensus CDS
      CCDS25100.1
      UniProtKB/Swiss-Prot
      Q6PD26
      UniProtKB/TrEMBL
      Q3U643, Q3V307
      Related
      ENSMUSP00000044871.9, ENSMUST00000048073.9
      Conserved Domains (1) summary
      pfam10510
      Location:22 → 546
      PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78219272..78233602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PD26.3 GenPept UniProtKB/Swiss-Prot:Q6PD26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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