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    Matcap1 microtubule associated tyrosine carboxypeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74356, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Matcap1provided by MGI
    Official Full Name
    microtubule associated tyrosine carboxypeptidase 1provided by MGI
    Primary source
    MGI:MGI:1921606
    See related
    Ensembl:ENSMUSG00000014837 AllianceGenome:MGI:1921606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MATCAP; Kiaa0895l; 4931428F04Rik
    Summary
    Predicted to enable tubulin-tyrosine carboxypeptidase. Involved in brain development. Predicted to be located in cytoplasm. Predicted to be active in microtubule. Orthologous to human MATCAP1 (microtubule associated tyrosine carboxypeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 28.7), whole brain E14.5 (RPKM 27.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Matcap1 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106007041..106016160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105280409..105289528, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8260 Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain) Neighboring gene STARR-positive B cell enhancer ABC_E1768 Neighboring gene STARR-positive B cell enhancer ABC_E3797 Neighboring gene uncharacterized LOC102636360 Neighboring gene exocyst complex component 3-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, et al. Science, 2022 May 20. PMID 35482892
    2. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables tubulin-tyrosine carboxypeptidase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin-tyrosine carboxypeptidase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated tyrosine carboxypeptidase 1; microtubule-associated tyrosine carboxypeptidase
    NP_001159866.1
    NP_083164.1
    XP_006531496.1
    XP_017168480.1
    XP_036010229.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166394.1 → NP_001159866.1  microtubule-associated tyrosine carboxypeptidase 1

      See identical proteins and their annotated locations for NP_001159866.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK016481, BC043046, CJ064766
      Consensus CDS
      CCDS22596.1
      UniProtKB/Swiss-Prot
      Q810A5, Q9D4J6
      Related
      ENSMUSP00000014981.7, ENSMUST00000014981.8
      Conserved Domains (1) summary
      cl06858
      Location:233 → 424
      DUF1704; Domain of unknown function (DUF1704)

    2. NM_028888.2 → NP_083164.1  microtubule-associated tyrosine carboxypeptidase 1

      See identical proteins and their annotated locations for NP_083164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC043046, CJ064766
      Consensus CDS
      CCDS22596.1
      UniProtKB/Swiss-Prot
      Q810A5, Q9D4J6
      Related
      ENSMUSP00000128530.2, ENSMUST00000171788.8
      Conserved Domains (1) summary
      cl06858
      Location:233 → 424
      DUF1704; Domain of unknown function (DUF1704)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106007041..106016160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154336.1 → XP_036010229.1  microtubule-associated tyrosine carboxypeptidase isoform X1

      Conserved Domains (1) summary
      cl06858
      Location:263 → 454
      DUF1704; Domain of unknown function (DUF1704)

    2. XM_017312991.3 → XP_017168480.1  microtubule-associated tyrosine carboxypeptidase isoform X1

      Conserved Domains (1) summary
      cl06858
      Location:263 → 454
      DUF1704; Domain of unknown function (DUF1704)

    3. XM_006531433.4 → XP_006531496.1  microtubule-associated tyrosine carboxypeptidase isoform X2

      See identical proteins and their annotated locations for XP_006531496.1

      UniProtKB/Swiss-Prot
      Q810A5, Q9D4J6
      Related
      ENSMUSP00000148836.2, ENSMUST00000212219.2
      Conserved Domains (1) summary
      cl06858
      Location:233 → 424
      DUF1704; Domain of unknown function (DUF1704)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810A5.1 GenPept UniProtKB/Swiss-Prot:Q810A5

    Gene LinkOut

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