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    Dpp3 dipeptidylpeptidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 75221, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dpp3provided by MGI
    Official Full Name
    dipeptidylpeptidase 3provided by MGI
    Primary source
    MGI:MGI:1922471
    See related
    Ensembl:ENSMUSG00000063904 AllianceGenome:MGI:1922471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DPP III; 4930533O14Rik
    Summary
    Predicted to enable dipeptidyl-peptidase activity and zinc ion binding activity. Predicted to be involved in protein catabolic process and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DPP3 (dipeptidyl peptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 86.3), colon adult (RPKM 70.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpp3 in Genome Data Viewer
    Location:
    19 A; 19 4.15 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4957257..4978315, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4907229..4928287, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3236 Neighboring gene zinc finger, DHHC domain containing 24 Neighboring gene STARR-seq mESC enhancer starr_45368 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene pellino 3 Neighboring gene STARR-seq mESC enhancer starr_45369 Neighboring gene STARR-seq mESC enhancer starr_45370 Neighboring gene mitochondrial ribosomal protein L11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling. Ren X, et al. Int Immunopharmacol, 2021 Jul. PMID 33812256
    2. Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice. Jha S, et al. J Biol Chem, 2020 Oct 2. PMID 32546481, Free PMC Article
    3. Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss. Menale C, et al. J Bone Miner Res, 2019 Nov. PMID 31295380, Free PMC Article
    4. DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma. Liu JK, et al. Oncol Rep, 2023 Jan. PMID 36382663, Free PMC Article
    5. Peptidases released by necrotic cells control CD8+ T cell cross-priming. Gamrekelashvili J, et al. J Clin Invest, 2013 Nov. PMID 24216478, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
      Title: DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.
    2. Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.
      Title: Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.
    3. Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
      Title: Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
    4. Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
      Title: Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.
    5. the cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation
      Title: Peptidases released by necrotic cells control CD8+ T cell cross-priming.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 3
    Names
    dipeptidyl aminopeptidase III
    dipeptidyl arylamidase III
    dipeptidyl peptidase III
    dipeptidyl-peptidase 3
    dipeptidylpeptidase III
    enkephalinase B
    NP_001347640.1
    NP_598564.2
    XP_036017612.1
    XP_036017613.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360711.1 → NP_001347640.1  dipeptidyl peptidase 3

      Status: VALIDATED

      Source sequence(s)
      AC124502, AC141437
      Consensus CDS
      CCDS29443.1
      UniProtKB/Swiss-Prot
      Q8C0I6, Q99KK7
      UniProtKB/TrEMBL
      Q3UDD5, Q3UDF3
      Conserved Domains (1) summary
      pfam03571
      Location:147 → 704
      Peptidase_M49; Peptidase family M49

    2. NM_133803.2 → NP_598564.2  dipeptidyl peptidase 3

      See identical proteins and their annotated locations for NP_598564.2

      Status: VALIDATED

      Source sequence(s)
      AK031020, AK150101, BY131486
      Consensus CDS
      CCDS29443.1
      UniProtKB/Swiss-Prot
      Q8C0I6, Q99KK7
      UniProtKB/TrEMBL
      Q3UDD5, Q3UDF3
      Related
      ENSMUSP00000025851.4, ENSMUST00000025851.4
      Conserved Domains (1) summary
      pfam03571
      Location:147 → 704
      Peptidase_M49; Peptidase family M49

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4957257..4978315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161719.1 → XP_036017612.1  dipeptidyl peptidase 3 isoform X1

      Conserved Domains (1) summary
      pfam03571
      Location:1 → 427
      Peptidase_M49; Peptidase family M49

    2. XM_036161720.1 → XP_036017613.1  dipeptidyl peptidase 3 isoform X1

      Conserved Domains (1) summary
      pfam03571
      Location:1 → 427
      Peptidase_M49; Peptidase family M49
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KK7.2 GenPept UniProtKB/Swiss-Prot:Q99KK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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