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    Idh3b isocitrate dehydrogenase 3 (NAD+) beta [ Mus musculus (house mouse) ]

    Gene ID: 170718, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Idh3bprovided by MGI
    Official Full Name
    isocitrate dehydrogenase 3 (NAD+) betaprovided by MGI
    Primary source
    MGI:MGI:2158650
    See related
    Ensembl:ENSMUSG00000027406 AllianceGenome:MGI:2158650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable NAD binding activity; magnesium ion binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Part of isocitrate dehydrogenase complex (NAD+). Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 305.9), kidney adult (RPKM 164.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Idh3b in Genome Data Viewer
    Location:
    2 F1; 2 63.2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130121229..130126371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130279309..130284451, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NOP56 ribonucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E3405 Neighboring gene predicted gene, 23650 Neighboring gene small nucleolar RNA, C/D box 57 Neighboring gene STARR-seq mESC enhancer starr_05691 Neighboring gene early B cell factor 4 Neighboring gene predicted gene, 39936 Neighboring gene ribosomal protein L27A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability. Zhu S, et al. J Biol Chem, 2022 Sep. PMID 35985423, Free PMC Article
    2. Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function. Findlay AS, et al. Dis Model Mech, 2018 Dec 18. PMID 30478029, Free PMC Article
    3. A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology. Wang X, et al. Signal Transduct Target Ther, 2024 Apr 29. PMID 38679634, Free PMC Article
    4. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
    5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A positive feedback inhibition of isocitrate dehydrogenase 3beta on paired-box gene 6 promotes Alzheimer-like pathology.
      Title: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology.
    2. Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.
      Title: Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of isocitrate dehydrogenase complex (NAD+) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of isocitrate dehydrogenase complex (NAD+) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    Names
    N14A tumor-related protein
    isocitrate dehydrogenase 3 beta
    NP_001349681.1
    NP_570954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362752.1 → NP_001349681.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL833804
      UniProtKB/TrEMBL
      A0A668KL51
      Related
      ENSMUSP00000159209.2, ENSMUST00000239288.2
      Conserved Domains (1) summary
      cl00445
      Location:46 → 376
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    2. NM_130884.4 → NP_570954.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_570954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL833804, AW049896, BY336999, CN456483, DN176034
      Consensus CDS
      CCDS16738.1
      UniProtKB/TrEMBL
      Q91VA7
      Related
      ENSMUSP00000028892.5, ENSMUST00000028892.11
      Conserved Domains (1) summary
      cl00445
      Location:46 → 379
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130121229..130126371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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