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    Rabgap1l RAB GTPase activating protein 1-like [ Mus musculus (house mouse) ]

    Gene ID: 29809, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rabgap1lprovided by MGI
    Official Full Name
    RAB GTPase activating protein 1-likeprovided by MGI
    Primary source
    MGI:MGI:1352507
    See related
    Ensembl:ENSMUSG00000026721 AllianceGenome:MGI:1352507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HHL; Hh1; mKIAA0471; 5830411O09Rik; 8430421H08Rik; 9630005B12Rik
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in regulation of protein localization. Predicted to be located in Golgi apparatus; early endosome; and nucleus. Is expressed in several structures, including heart; immune system; nervous system; retina nuclear layer; and yolk sac. Orthologous to human RABGAP1L (RAB GTPase activating protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 3.6), CNS E18 (RPKM 3.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rabgap1l in Genome Data Viewer
    Location:
    1 H2.1; 1 69.64 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160046744..160621046, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (160219174..160793476, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02795 Neighboring gene RIKEN cDNA 4933417C20 gene Neighboring gene STARR-seq mESC enhancer starr_02796 Neighboring gene STARR-seq mESC enhancer starr_02797 Neighboring gene STARR-seq mESC enhancer starr_02798 Neighboring gene STARR-positive B cell enhancer ABC_E9188 Neighboring gene STARR-positive B cell enhancer ABC_E5830 Neighboring gene STARR-positive B cell enhancer ABC_E5831 Neighboring gene calcyclin binding protein Neighboring gene STARR-seq mESC enhancer starr_02799 Neighboring gene STARR-seq mESC enhancer starr_02800 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162237326-162237707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162239161-162239370 Neighboring gene microRNA 1927 Neighboring gene STARR-seq mESC enhancer starr_02802 Neighboring gene STARR-seq mESC enhancer starr_02803 Neighboring gene STARR-positive B cell enhancer ABC_E5832 Neighboring gene STARR-seq mESC enhancer starr_02805 Neighboring gene STARR-seq mESC enhancer starr_02807 Neighboring gene G protein-coupled receptor 52 Neighboring gene predicted gene, 23528 Neighboring gene STARR-seq mESC enhancer starr_02810 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162722911-162723212 Neighboring gene STARR-positive B cell enhancer ABC_E7764 Neighboring gene predicted gene, 37083 Neighboring gene STARR-positive B cell enhancer ABC_E5833 Neighboring gene STARR-positive B cell enhancer ABC_E8983 Neighboring gene predicted gene, 24988 Neighboring gene ribosomal protein L23A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. Qu F, et al. Elife, 2016 Oct 8. PMID 27718357, Free PMC Article
    2. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Hidaka M, et al. Mech Dev, 2000 Jan. PMID 10585558
    3. Large-scale phosphorylation analysis of mouse liver. Villén J, et al. Proc Natl Acad Sci U S A, 2007 Jan 30. PMID 17242355, Free PMC Article
    4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in megakaryocyte development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rab GTPase-activating protein 1-like
    Names
    rab6 GTPase activating protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038621.2 → NP_001033710.1  rab GTPase-activating protein 1-like isoform b

      See identical proteins and their annotated locations for NP_001033710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK147634
      Consensus CDS
      CCDS15407.1
      UniProtKB/Swiss-Prot
      A6H6A9
      Related
      ENSMUSP00000028052.6, ENSMUST00000028052.12
      Conserved Domains (1) summary
      TIGR02168
      Location:113 → 322
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_013862.5 → NP_038890.3  rab GTPase-activating protein 1-like isoform a

      See identical proteins and their annotated locations for NP_038890.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC154873, AK035796, BC145811
      Consensus CDS
      CCDS15408.1
      UniProtKB/Swiss-Prot
      A6H6A9, Q3UH20, Q80TZ4, Q8BZD2, Q8BZP0, Q8CFI6, Q9QY69
      Related
      ENSMUSP00000028049.8, ENSMUST00000028049.13
      Conserved Domains (3) summary
      cd01211
      Location:129 → 257
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:541 → 744
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:340 → 421
      DUF3694; Kinesin protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160046744..160621046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496875.1 → XP_006496938.1  rab GTPase-activating protein 1-like isoform X1

      Conserved Domains (4) summary
      COG1196
      Location:814 → 1019
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:129 → 257
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:541 → 744
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:290 → 421
      DUF3694; Kinesin protein

    2. XM_006496878.4 → XP_006496941.1  rab GTPase-activating protein 1-like isoform X4

      Conserved Domains (4) summary
      COG1196
      Location:756 → 961
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:71 → 199
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:483 → 686
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:232 → 363
      DUF3694; Kinesin protein

    3. XM_006496876.2 → XP_006496939.1  rab GTPase-activating protein 1-like isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:786 → 991
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:101 → 229
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:513 → 716
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:262 → 393
      DUF3694; Kinesin protein

    4. XM_006496877.3 → XP_006496940.1  rab GTPase-activating protein 1-like isoform X3

      Conserved Domains (4) summary
      COG1196
      Location:777 → 982
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:92 → 220
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:504 → 707
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:253 → 384
      DUF3694; Kinesin protein

    5. XM_006496881.5 → XP_006496944.1  rab GTPase-activating protein 1-like isoform X6

      Conserved Domains (1) summary
      COG1196
      Location:68 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_030254804.2 → XP_030110664.1  rab GTPase-activating protein 1-like isoform X7

      Conserved Domains (1) summary
      COG1196
      Location:62 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_030254802.2 → XP_030110662.1  rab GTPase-activating protein 1-like isoform X6

      Conserved Domains (1) summary
      COG1196
      Location:68 → 276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_036165642.1 → XP_036021535.1  rab GTPase-activating protein 1-like isoform X5

      Conserved Domains (3) summary
      cd01211
      Location:101 → 229
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00566
      Location:513 → 716
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam12473
      Location:262 → 393
      DUF3694; Kinesin protein

    9. XM_030254805.1 → XP_030110665.1  rab GTPase-activating protein 1-like isoform X8

    10. XM_006496883.5 → XP_006496946.1  rab GTPase-activating protein 1-like isoform X9

      See identical proteins and their annotated locations for XP_006496946.1

      UniProtKB/Swiss-Prot
      A6H6A9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H6A9.1 GenPept UniProtKB/Swiss-Prot:A6H6A9

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