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    CNTN6 contactin 6 [ Homo sapiens (human) ]

    Gene ID: 27255, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CNTN6provided by HGNC
    Official Full Name
    contactin 6provided by HGNC
    Primary source
    HGNC:HGNC:2176
    See related
    Ensembl:ENSG00000134115 MIM:607220; AllianceGenome:HGNC:2176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NB3
    Summary
    The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in thyroid (RPKM 3.8), lung (RPKM 1.4) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CNTN6 in Genome Data Viewer
    Location:
    3p26.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (1093024..1404217)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (870677..1398549)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (1134708..1445901)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986059 Neighboring gene NANOG hESC enhancer GRCh37_chr3:933147-933648 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:946672-947487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:1002002-1002502 Neighboring gene RNA, 7SL, cytoplasmic 120, pseudogene Neighboring gene uncharacterized LOC105376924 Neighboring gene uncharacterized LOC105376923 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:1277185-1278384 Neighboring gene crumbs cell polarity complex component 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:1642422-1642922 Neighboring gene ribosomal protein L23a pseudogene 38 Neighboring gene meiotic recombination hotspot S Neighboring gene ribosomal protein L23a pseudogene 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism, Mediates Thyroid Hormone Biosynthesis Through Notch Signaling.
      Title: Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism, Mediates Thyroid Hormone Biosynthesis Through Notch Signaling.
    2. CNTN6 copy number variations: Uncertain clinical significance in individuals with neurodevelopmental disorders.
      Title: CNTN6 copy number variations: Uncertain clinical significance in individuals with neurodevelopmental disorders.
    3. this study describes of 2 boys with intellectual disability, attention-deficit hyperactivity disorder harboring a 3p26.3 microdeletion and a 3p26.3 microduplication, which are both paternally inherited and include only the CNTN6 gene.
      Title: Clinical and Molecular Characterization of Two Patients with CNTN6 Copy Number Variations.
    4. Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway.
      Title: CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.
    5. CNTN6 copy number variants (duplications) were associated with increased risk of Tourette syndrome.
      Title: Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome.
    6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. results do not support the candidacy of CHL1, CNTN6, and CNTN4 as tumor suppressor genes in the 3p26-pter region in ovarian cancer
      Title: Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2022-09-28)

    ClinGen Genome Curation PagePubMed
    Haploinsufficency

    No evidence available (Last evaluated 2022-09-28)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
    EBI GWAS Catalog
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133256, AC087430.1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    contactin-6
    Names
    neural adhesion molecule
    neural recognition molecule NB-3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047144.1 RefSeqGene

      Range
      89890..401083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001289080.2 → NP_001276009.1  contactin-6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001276009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 4-9 all encode the same isoform (1).
      Source sequence(s)
      AB003592, AC026214, AC034192, BC113118, CN364480, DB170583
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Related
      ENSP00000407822.2, ENST00000446702.7
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    2. NM_001289081.2 → NP_001276010.1  contactin-6 isoform 2

      See identical proteins and their annotated locations for NP_001276010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC026214, AC034192, AK294786, BC113118, CN364480, DA094373
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (5) summary
      cd04969
      Location:352 → 424
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:434 → 522
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:336 → 424
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:247 → 331
      Ig; Immunoglobulin domain

    3. NM_001349350.2 → NP_001336279.1  contactin-6 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 2, and 5-9, encodes isoform 1.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    4. NM_001349351.2 → NP_001336280.1  contactin-6 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, 4, and 6-9, encodes isoform 1.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    5. NM_001349352.2 → NP_001336281.1  contactin-6 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 4, 5, and 7-9, encodes isoform 1.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    6. NM_001349353.2 → NP_001336282.1  contactin-6 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 4-6, 8 and 9, encodes isoform 1.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    7. NM_001349354.2 → NP_001336283.1  contactin-6 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 4-7, and 9, encodes isoform 1.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    8. NM_001349355.2 → NP_001336284.1  contactin-6 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, and 4-8, encodes isoform 1.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    9. NM_001349356.2 → NP_001336285.1  contactin-6 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform 3.
      Source sequence(s)
      AC026214, AC027123, AC034192
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:562 → 655
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:283 → 367
      Ig; Immunoglobulin domain

    10. NM_001349357.2 → NP_001336286.1  contactin-6 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes isoform 4.
      Source sequence(s)
      AC026214, AC027123, AC034192
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:494 → 587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:215 → 299
      Ig; Immunoglobulin domain

    11. NM_001349358.2 → NP_001336287.1  contactin-6 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) encodes isoform 5.
      Source sequence(s)
      AC026214, AC027123, AC034192
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (3) summary
      smart00060
      Location:718 → 798
      FN3; Fibronectin type 3 domain
      cd00063
      Location:413 → 506
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:330 → 413
      Ig; Immunoglobulin domain

    12. NM_001349359.2 → NP_001336288.1  contactin-6 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 14-16, encodes isoform 6.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Conserved Domains (3) summary
      smart00060
      Location:529 → 609
      FN3; Fibronectin type 3 domain
      cd00063
      Location:224 → 317
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:141 → 224
      Ig; Immunoglobulin domain

    13. NM_001349360.2 → NP_001336289.1  contactin-6 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 13, 15, and 16, encodes isoform 6.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Conserved Domains (3) summary
      smart00060
      Location:529 → 609
      FN3; Fibronectin type 3 domain
      cd00063
      Location:224 → 317
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:141 → 224
      Ig; Immunoglobulin domain

    14. NM_001349361.2 → NP_001336290.1  contactin-6 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 13, 14, and 16, encodes isoform 6.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Conserved Domains (3) summary
      smart00060
      Location:529 → 609
      FN3; Fibronectin type 3 domain
      cd00063
      Location:224 → 317
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:141 → 224
      Ig; Immunoglobulin domain

    15. NM_001349362.2 → NP_001336291.1  contactin-6 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 13-15, encodes isoform 6.
      Source sequence(s)
      AC026214, AC027123, AC034192
      Conserved Domains (3) summary
      smart00060
      Location:529 → 609
      FN3; Fibronectin type 3 domain
      cd00063
      Location:224 → 317
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:141 → 224
      Ig; Immunoglobulin domain

    16. NM_014461.4 → NP_055276.1  contactin-6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_055276.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 2, and 4-9 all encode the same isoform (1).
      Source sequence(s)
      AB003592, AC026214, AC034192, BC036338, CN364480
      Consensus CDS
      CCDS2557.1
      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Related
      ENSP00000341882.2, ENST00000350110.2
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      1093024..1404217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533590.3 → XP_011531892.1  contactin-6 isoform X1

      See identical proteins and their annotated locations for XP_011531892.1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    2. XM_047447972.1 → XP_047303928.1  contactin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52

    3. XM_047447974.1 → XP_047303930.1  contactin-6 isoform X4

    4. XM_017006177.3 → XP_016861666.1  contactin-6 isoform X3

    5. XM_017006172.3 → XP_016861661.1  contactin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52
      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (2) summary
      cd00063
      Location:598 → 691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:319 → 403
      Ig; Immunoglobulin domain

    6. XM_011533591.4 → XP_011531893.1  contactin-6 isoform X2

      See identical proteins and their annotated locations for XP_011531893.1

      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (5) summary
      cd04969
      Location:352 → 424
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:434 → 522
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:336 → 424
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:247 → 331
      Ig; Immunoglobulin domain

    7. XM_017006174.2 → XP_016861663.1  contactin-6 isoform X2

      UniProtKB/TrEMBL
      B4DGV0
      Conserved Domains (5) summary
      cd04969
      Location:352 → 424
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:434 → 522
      IG_like; Immunoglobulin like
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:336 → 424
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:247 → 331
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      870677..1398549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346182.1 → XP_054202157.1  contactin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52

    2. XM_054346183.1 → XP_054202158.1  contactin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52

    3. XM_054346188.1 → XP_054202163.1  contactin-6 isoform X4

    4. XM_054346187.1 → XP_054202162.1  contactin-6 isoform X3

    5. XM_054346184.1 → XP_054202159.1  contactin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52

    6. XM_054346181.1 → XP_054202156.1  contactin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHM2, Q9UQ52

    7. XM_054346186.1 → XP_054202161.1  contactin-6 isoform X2

    8. XM_054346185.1 → XP_054202160.1  contactin-6 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UQ52.1 GenPept UniProtKB/Swiss-Prot:Q9UQ52

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