HRH4 histamine receptor H4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HRH4provided by HGNC
Official Full Name: histamine receptor H4provided by HGNC
Primary source: HGNC:HGNC:17383
See related: Ensembl:ENSG00000134489 MIM:606792; AllianceGenome:HGNC:17383
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105
Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 18q11.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (24460637..24479974)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (24654947..24674284)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (22040601..22059938)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histamine H1- and H4-receptor expression in human colon-derived cell lines.
Title: Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.
Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases.
Title: Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases.
Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
Title: Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study.
Title: Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study.
Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.
Title: Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.
Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor.
Title: Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor.
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
Title: Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
HRH4 rs77485247 polymorphism may be an important mediator in regulating proinflammatory cytokines
Title: Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease.
our present study confirmed the expression of H4R in ESCC, which was closely associated with clinicopathological features, including histological grades, primary tumor size, lymph node metastasis, and patient survival.
Title: Activation of histamine H(4) receptor suppresses the proliferation and invasion of esophageal squamous cell carcinoma via both metabolism and non-metabolism signaling pathways.
ur data indicate that the H4 peptide tail promotes the formation of active strand transfer complexes (STCs) and support an activation step of the incoming intasome at the contact of the histone tail.
Title: Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482834

NoName (e-PCR)
- UniSTS:480942

GDB:631802 (e-PCR)
- UniSTS:158429

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histamine H4 receptor

Names: G-protein coupled receptor 105; SP9144; pfi-013

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143828.2 → NP_001137300.1 histamine H4 receptor isoform 2

See identical proteins and their annotated locations for NP_001137300.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, also known as H4R(302), which is shorter than isoform 1.

Source sequence(s)

AC007922, AF312230, BC069136, DQ835186

Consensus CDS

CCDS45841.1

UniProtKB/Swiss-Prot

Q9H3N8

Related

ENSP00000402526.2, ENST00000426880.2

Conserved Domains (1) summary

pfam00001
Location:211 → 270

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001160166.2 → NP_001153638.1 histamine H4 receptor isoform 3

See identical proteins and their annotated locations for NP_001153638.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate coding exon resulting in a frameshift, compared to variant 1. The resulting isoform (3), also known as H4R(67), has a substantially shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC007922, AF312230, BC069136, DQ835187

UniProtKB/TrEMBL

B2KJ49

Conserved Domains (2) summary

cd14964
Location:18 → 42

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:16 → 67

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_021624.4 → NP_067637.2 histamine H4 receptor isoform 1

See identical proteins and their annotated locations for NP_067637.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC007922, AF312230

Consensus CDS

CCDS11887.1

UniProtKB/Swiss-Prot

B0YJ19, B2KJ48, Q4G0I6, Q9GZQ0, Q9H3N8

UniProtKB/TrEMBL

Q96LD9

Related

ENSP00000256906.4, ENST00000256906.5

Conserved Domains (1) summary

cd15295
Location:16 → 374

7tmA_Histamine_H4R; histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors