DPEP1 dipeptidase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DPEP1provided by HGNC
Official Full Name: dipeptidase 1provided by HGNC
Primary source: HGNC:HGNC:3002
See related: Ensembl:ENSG00000015413 MIM:179780; AllianceGenome:HGNC:3002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MDP; RDP; MBD1
Summary: The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
Expression: Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q24.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (89613308..89641540)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (95694848..95725329)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (89679716..89707948)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
Title: Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.
Title: DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.
The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.
Title: The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
Title: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
Title: DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
Title: DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
The results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer.
Title: Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.
In this study, we present an analysis of Neanderthal introgression at the dipeptidase 1 gene, DPEP1.
Title: Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression.
Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification.
Title: Dipeptidase 1 (DPEP1) is a marker for the transition from low-grade to high-grade intraepithelial neoplasia and an adverse prognostic factor in colorectal cancer.
DPEP1 plays a role in pancreatic cancer aggressiveness.
Title: DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GPI anchor binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-lactamase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallodipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloexopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables modified amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antibiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nitric oxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in homocysteine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lactam catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in leukotriene D4 catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dipeptidase 1

Names: beta-lactamase; dehydropeptidase-I; dipeptidase 1 (renal); hRDP; microsomal dipeptidase; renal dipeptidase; testicular tissue protein Li 57

NP_001121613.1

EC 3.4.13.19

EC 3.5.2.6

NP_001376395.1

EC 3.4.13.19

EC 3.5.2.6

NP_001376396.1

EC 3.4.13.19

EC 3.5.2.6

NP_001376397.1

EC 3.4.13.19

EC 3.5.2.6

NP_001376398.1

EC 3.4.13.19

EC 3.5.2.6

NP_001376399.1

EC 3.4.13.19

EC 3.5.2.6

NP_001376400.1

EC 3.4.13.19

EC 3.5.2.6

NP_004404.1

EC 3.4.13.19

EC 3.5.2.6

XP_024305941.1

EC 3.4.13.19

EC 3.5.2.6

XP_047289646.1

EC 3.4.13.19

EC 3.5.2.6

XP_047289647.1

EC 3.4.13.19

EC 3.5.2.6

XP_047289649.1

EC 3.4.13.19

EC 3.5.2.6

XP_054235704.1

EC 3.4.13.19

EC 3.5.2.6

XP_054235705.1

EC 3.4.13.19

EC 3.5.2.6

XP_054235706.1

EC 3.4.13.19

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128141.3 → NP_001121613.1 dipeptidase 1 isoform a precursor

See identical proteins and their annotated locations for NP_001121613.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), as well as variants 1 and 3-6, encodes isoform a.

Source sequence(s)

AC010538, BC017023, BM152944

Consensus CDS

CCDS10982.1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3, Q6I9V1

Related

ENSP00000397313.1, ENST00000421184.5

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_001389466.1 → NP_001376395.1 dipeptidase 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.

Source sequence(s)

AC010538

Consensus CDS

CCDS10982.1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3, Q6I9V1

Related

ENSP00000508584.1, ENST00000690203.1

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_001389467.1 → NP_001376396.1 dipeptidase 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6, encodes isoform a.

Source sequence(s)

AC010538

Consensus CDS

CCDS10982.1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3, Q6I9V1

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_001389468.1 → NP_001376397.1 dipeptidase 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 1-4 and 6, encodes isoform a.

Source sequence(s)

AC010538

Consensus CDS

CCDS10982.1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3, Q6I9V1

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_001389469.1 → NP_001376398.1 dipeptidase 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.

Source sequence(s)

AC010538, BC017023

Consensus CDS

CCDS10982.1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3, Q6I9V1

Related

ENSP00000261615.4, ENST00000261615.5

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_001389470.1 → NP_001376399.1 dipeptidase 1 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variant 8, encodes isoform b.

Source sequence(s)

AC010538

UniProtKB/TrEMBL

Q6I9V1

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_001389471.1 → NP_001376400.1 dipeptidase 1 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variant 7, encodes isoform b.

Source sequence(s)

AC010538

UniProtKB/TrEMBL

Q6I9V1

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
NM_004413.4 → NP_004404.1 dipeptidase 1 isoform a precursor

See identical proteins and their annotated locations for NP_004404.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), as well as variants 2-6, encodes isoform a.

Source sequence(s)

AC010538, BC017023, J05257

Consensus CDS

CCDS10982.1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3, Q6I9V1

Related

ENSP00000376807.3, ENST00000393092.7

Conserved Domains (1) summary

pfam01244
Location:26 → 352

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

89613308..89641540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047433691.1 → XP_047289647.1 dipeptidase 1 isoform X2
XM_047433690.1 → XP_047289646.1 dipeptidase 1 isoform X1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3
XM_047433693.1 → XP_047289649.1 dipeptidase 1 isoform X1

UniProtKB/Swiss-Prot

D3DX80, P16444, Q96AK2

UniProtKB/TrEMBL

A0A140VJI3
XM_024450173.2 → XP_024305941.1 dipeptidase 1 isoform X3

UniProtKB/TrEMBL

Q6I9V1

Conserved Domains (1) summary

pfam01244
Location:5 → 307

Peptidase_M19; Membrane dipeptidase (Peptidase family M19)