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    Cd8b CD8 subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24931, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd8bprovided by RGD
    Official Full Name
    CD8 subunit betaprovided by RGD
    Primary source
    RGD:2317
    See related
    EnsemblRapid:ENSRNOG00000007129 AllianceGenome:RGD:2317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd8b1
    Summary
    Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in T cell activation and T cell receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in cell surface. Orthologous to several human genes including CD8B (CD8 subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 999.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd8b in Genome Data Viewer
    Location:
    4q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (104870911..104886838)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103312596..103328523)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99185960..99201887)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene lysine-rich coiled-coil 1 Neighboring gene zinc finger, matrin-type 1 like 1 Neighboring gene uncharacterized LOC134486799 Neighboring gene tubulin, alpha 1B, pseudogene 8 Neighboring gene CD8 subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen. Johnson P, et al. Nature, 1986 Sep 4-10. PMID 3092111
    2. The protective effect of CD8+CD28- T suppressor cells on the acute rejection responses in rat liver transplantation. Liu Y, et al. Transplant Proc, 2007 Dec. PMID 18089392
    3. Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. Kerry SE, et al. J Immunol, 2003 Nov 1. PMID 14568922, Free PMC Article
    4. CD8 is needed for development of cytotoxic T cells but not helper T cells. Fung-Leung WP, et al. Cell, 1991 May 3. PMID 1673361
    5. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Allam A, et al. Immunobiology, 2000 Nov. PMID 11131152

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD8 positive T suppressor cells protect allogenic recipients from acute rejection in rats liver transplantation.
      Title: The protective effect of CD8+CD28- T suppressor cells on the acute rejection responses in rat liver transplantation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class I protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD8 beta chain
    Names
    CD8 antigen 37 kDa chain
    CD8 antigen beta-chain
    CD8b molecule
    OX-8 membrane antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031539.2 → NP_113727.2  T-cell surface glycoprotein CD8 beta chain precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IA70, G3V6V7, Q6PCV0
      Related
      ENSRNOP00000009392.6, ENSRNOT00000009392.9
      Conserved Domains (1) summary
      cd07700
      Location:22 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      104870911..104886838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05541.1 GenPept UniProtKB/Swiss-Prot:P05541

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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