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    TMEM179 transmembrane protein 179 [ Homo sapiens (human) ]

    Gene ID: 388021, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM179provided by HGNC
    Official Full Name
    transmembrane protein 179provided by HGNC
    Primary source
    HGNC:HGNC:20137
    See related
    Ensembl:ENSG00000258986 AllianceGenome:HGNC:20137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf90; TMEM179A
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 3.6), adrenal (RPKM 2.8) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM179 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (104590864..104604772, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (98833645..98847553, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105057201..105071109, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903395 Neighboring gene MPRA-validated peak2256 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105029496-105030057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105030714-105031460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105031461-105032205 Neighboring gene MPRA-validated peak2258 silencer Neighboring gene chromosome 14 open reading frame 180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105053553-105054112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105054113-105054670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6187 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:105119263-105119764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105122182-105122682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105122683-105123183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105125610-105126204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105126205-105126799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105128863-105129362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105131825-105132587 Neighboring gene long intergenic non-protein coding RNA 2280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105143259-105143816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105143817-105144373 Neighboring gene microRNA 4710

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells. He Z, et al. Ecotoxicol Environ Saf, 2021 Oct 15. PMID 34332247
    2. The DNA sequence and analysis of human chromosome 14. Heilig R, et al. Nature, 2003 Feb 6. PMID 12508121
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Clone Names

    • FLJ42486

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 179
    Names
    transmembrane protein 179A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286389.2 → NP_001273318.1  transmembrane protein 179 isoform 1

      See identical proteins and their annotated locations for NP_001273318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK124477, AW026835, BX927359
      Consensus CDS
      CCDS66723.1
      UniProtKB/Swiss-Prot
      Q6ZVK1
      Related
      ENSP00000450958.1, ENST00000556573.6

    2. NM_001286390.2 → NP_001273319.1  transmembrane protein 179 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI299168, AK124477, AW026835, BX927359
      Consensus CDS
      CCDS73688.1
      UniProtKB/TrEMBL
      A0A087X0S3, A0A0G2JNH9
      Related
      ENSP00000483627.1, ENST00000615704.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      104590864..104604772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536745.3 → XP_011535047.1  transmembrane protein 179 isoform X2

      See identical proteins and their annotated locations for XP_011535047.1

    2. XM_011536750.2 → XP_011535052.1  transmembrane protein 179 isoform X3

      See identical proteins and their annotated locations for XP_011535052.1

    3. XM_024449578.2 → XP_024305346.1  transmembrane protein 179 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JNH9
      Related
      ENSP00000397763.2, ENST00000415614.6

    RNA

    1. XR_002957551.2 RNA Sequence

    2. XR_007064011.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187599.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      148687..162595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328948.1 → XP_054184923.1  transmembrane protein 179 isoform X2

    2. XM_054328950.1 → XP_054184925.1  transmembrane protein 179 isoform X3

    3. XM_054328949.1 → XP_054184924.1  transmembrane protein 179 isoform X2

    4. XM_054328951.1 → XP_054184926.1  transmembrane protein 179 isoform X3

    5. XM_054328947.1 → XP_054184922.1  transmembrane protein 179 isoform X1

    RNA

    1. XR_008485614.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      98833645..98847553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376026.1 → XP_054232001.1  transmembrane protein 179 isoform X2

    2. XM_054376027.1 → XP_054232002.1  transmembrane protein 179 isoform X2

    3. XM_054376028.1 → XP_054232003.1  transmembrane protein 179 isoform X3

    4. XM_054376025.1 → XP_054232000.1  transmembrane protein 179 isoform X1

    RNA

    1. XR_008488867.1 RNA Sequence

    2. XR_008488868.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207379.1: Suppressed sequence

      Description
      NM_207379.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZVK1.2 GenPept UniProtKB/Swiss-Prot:Q6ZVK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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