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    TMEM132C transmembrane protein 132C [ Homo sapiens (human) ]

    Gene ID: 92293, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TMEM132Cprovided by HGNC
    Official Full Name
    transmembrane protein 132Cprovided by HGNC
    Primary source
    HGNC:HGNC:25436
    See related
    Ensembl:ENSG00000181234 AllianceGenome:HGNC:25436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPP1R152
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in fat (RPKM 20.4), endometrium (RPKM 2.3) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM132C in Genome Data Viewer
    Location:
    12q24.32-q24.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (128267170..128707911)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (128297066..128738704)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (128751715..129192456)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2368 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:128642903-128643556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:128674654-128675653 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:128743759-128744260 Neighboring gene uncharacterized LOC107987176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:128750861-128751382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:128751918-128752756 Neighboring gene microRNA 3612 Neighboring gene NANOG hESC enhancer GRCh37_chr12:128866078-128866579 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:128867427-128868398 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:128868399-128869369 Neighboring gene uncharacterized LOC124903115 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:128942780-128943732 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:128943733-128944685 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:129028409-129028584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5087 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:129141297-129142496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:129148562-129149148 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25284 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:129192543-129193044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:129193045-129193544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7327 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:129212543-129213042 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:129238411-129239610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129271367-129271867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129276413-129276913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7331 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:129281709-129282908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129286977-129287478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129287479-129287978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7339 Neighboring gene uncharacterized LOC124903083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7341 Neighboring gene uncharacterized LOC124903089 Neighboring gene solute carrier family 15 member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide association study of attempted suicide. Willour VL, et al. Mol Psychiatry, 2012 Apr. PMID 21423239, Free PMC Article
    2. TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Sanchez-Pulido L, et al. Bioinformatics, 2018 Mar 1. PMID 29088312, Free PMC Article
    3. Genome-wide association study in Han Chinese identifies three novel loci for human height. Hao Y, et al. Hum Genet, 2013 Jun. PMID 23456168
    4. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Chung S, et al. Breast Cancer Res, 2013. PMID 24025145, Free PMC Article
    5. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of attempted suicide.
    EBI GWAS Catalog
    A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
    EBI GWAS Catalog
    Genome-wide association study in Han Chinese identifies three novel loci for human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of transmembrane protein 132C (TMEM132C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761O2018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 132C
    Names
    protein phosphatase 1, regulatory subunit 152

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136103.3 → NP_001129575.2  transmembrane protein 132C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001129575.2

      Status: VALIDATED

      Source sequence(s)
      AC023595, AC061709, AC090424, AC107020
      Consensus CDS
      CCDS45009.2
      UniProtKB/Swiss-Prot
      Q69YX8, Q8N3T6
      Related
      ENSP00000410852.2, ENST00000435159.3
      Conserved Domains (3) summary
      pfam15705
      Location:51 → 181
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:893 → 979
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:438 → 780
      TMEM132; Transmembrane protein family 132

    2. NM_001387058.1 → NP_001373987.1  transmembrane protein 132C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC023595, AC061709, AC090424, AC107020
      Conserved Domains (3) summary
      pfam15705
      Location:31 → 161
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:873 → 957
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:418 → 761
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      128267170..128707911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429886.1 → XP_047285842.1  transmembrane protein 132C isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      128297066..128738704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373842.1 → XP_054229817.1  transmembrane protein 132C isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N3T6.3 GenPept UniProtKB/Swiss-Prot:Q8N3T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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