U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cdadc1 cytidine and dCMP deaminase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71891, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cdadc1provided by MGI
    Official Full Name
    cytidine and dCMP deaminase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919141
    See related
    Ensembl:ENSMUSG00000021982 AllianceGenome:MGI:1919141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NYD-SP15; 2310010M10Rik
    Summary
    Predicted to enable several functions, including deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Predicted to be involved in DNA cytosine deamination and cytidine deamination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human CDADC1 (cytidine and dCMP deaminase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 3.1), frontal lobe adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cdadc1 in Genome Data Viewer
    Location:
    14 C3; 14 31.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59796837..59835433, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59559386..59597985, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45935 Neighboring gene SET domain, bifurcated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4112 Neighboring gene calcium binding protein 39-like Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36842 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene shisa family member 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NYD-SP15 protein plays an important role in testicular development and spermatogenesis
      Title: NYD-SP15: a novel gene potentially involved in regulating testicular development and spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA cytosine deamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine deamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytidine and dCMP deaminase domain-containing protein 1
    Names
    cytidine deaminase
    NP_001162007.1
    NP_001162008.1
    NP_001162009.1
    NP_001162010.1
    NP_082262.1
    XP_011243506.1
    XP_030103902.1
    XP_036014747.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168535.1 → NP_001162007.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001162007.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC147044, AK032600, AK038926, BE648840, CX242881
      Consensus CDS
      CCDS49514.1
      UniProtKB/TrEMBL
      G3UW39
      Related
      ENSMUSP00000153357.2, ENSMUST00000225839.2
      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    2. NM_001168536.1 → NP_001162008.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001162008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK009280, AK039148, CX242881
      Consensus CDS
      CCDS49515.1
      UniProtKB/Swiss-Prot
      Q8BMD5
      Related
      ENSMUSP00000128064.2, ENSMUST00000171683.3
      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    3. NM_001168537.1 → NP_001162009.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001162009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC147044, AK032600, AK038926, BE648840, CX242881
      Consensus CDS
      CCDS49513.1
      UniProtKB/Swiss-Prot
      Q8BMD5
      Related
      ENSMUSP00000022555.4, ENSMUST00000022555.11
      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    4. NM_001168538.1 → NP_001162010.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC147044, AK032813, AK039148, CX242881
      Consensus CDS
      CCDS88678.1
      UniProtKB/Swiss-Prot
      Q8BMD5
      Related
      ENSMUSP00000128022.3, ENSMUST00000167100.9
      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    5. NM_027986.3 → NP_082262.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_082262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK032813, CO039661, CX242881
      Consensus CDS
      CCDS36940.1
      UniProtKB/Swiss-Prot
      Q8BMD5, Q8BYL2, Q8BYN1, Q8C014, Q922P4, Q99KL2, Q9D7F3
      Related
      ENSMUSP00000052233.8, ENSMUST00000056997.15
      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    RNA

    1. NR_153387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147044, AK032813, AK039148, CX242881

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      59796837..59835433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245204.4 → XP_011243506.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:83 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    2. XM_030248042.2 → XP_030103902.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl00269
      Location:20 → 139
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    3. XM_036158854.1 → XP_036014747.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl00269
      Location:20 → 139
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    RNA

    1. XR_004938452.1 RNA Sequence

    2. XR_004938455.1 RNA Sequence

    3. XR_004938454.1 RNA Sequence

    4. XR_004938451.1 RNA Sequence

    5. XR_004938450.1 RNA Sequence

    6. XR_004938448.1 RNA Sequence

    7. XR_004938449.1 RNA Sequence

    8. XR_004938456.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMD5.1 GenPept UniProtKB/Swiss-Prot:Q8BMD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools