fem1a fem-1 homolog a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fem1aprovided by ZNC
Official Full Name: fem-1 homolog aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5824
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-5824
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi20c04; zgc:63483; wu:fi20c04
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in regulation of inflammatory response; regulation of ubiquitin-protein transferase activity; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in cytoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in mitochondrion. Orthologous to human FEM1A (fem-1 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (58868156..58869454, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (58742735..58744033, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Z6123 (e-PCR)
- UniSTS:11802

G40466 (e-PCR)
- UniSTS:40812

z6766 (e-PCR), detects polymorphism
- UniSTS:204918

fi20c04.x1 (e-PCR)
- UniSTS:201654

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein fem-1 homolog A

Names: FEM1-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199837.1 → NP_956131.1 protein fem-1 homolog A

See identical proteins and their annotated locations for NP_956131.1

Status: PROVISIONAL

Source sequence(s)

BC060522

UniProtKB/Swiss-Prot

Q6P9Z4

Conserved Domains (5) summary

cd00204
Location:73 → 202

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:87 → 178

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:182 → 234

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:515 → 568

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:118 → 146

ANK; ANK repeat [structural motif]