Ftmt ferritin mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ftmtprovided by MGI
Official Full Name: ferritin mitochondrialprovided by MGI
Primary source: MGI:MGI:1914884
See related: Ensembl:ENSMUSG00000024510 AllianceGenome:MGI:1914884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MtF; FerH; Fth3; 4930447C24Rik
Summary: Enables ferroxidase activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Located in mitochondrion. Orthologous to human FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 18 D1; 18 28.19 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (52464608..52466068)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (52331536..52332996)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a model of FtMT overexpression, during dietary challenge, mice are leaner but exhibit glucose intolerance, low adiponectin levels, increased reactive oxygen species damage, and elevated GDF15 and FGF21 levels, indicating metabolically dysfunctional fat. Despite harboring highly dysfunctional fat, mice display massive beta-cell hyperplasia, reflecting a beneficial mitochondria-induced fat-to-pancreas interorgan signa...
Title: A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia.
Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
Title: Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin.
Title: Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
Our results provide evidence that the iron storage function of ferritin plays a major role in preventing iron-mediated cell and tissue damage.
Title: Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage.
ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance
Title: Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo.
ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation
Title: Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.
ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritin H mRNA.
Title: Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization.
Its association with cell types characterized by high metabolic activity and oxygen consumption suggests a role in protecting mitochondria from iron-dependent oxidative damage.
Title: Mitochondrial ferritin expression in adult mouse tissues.
PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene
Title: PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element.
overexpression of MtFt causes a dramatic change in intracellular iron homeostasis and shunting iron to MtFt likely limits its availability for active iron proteins
Title: Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferroxidase activity	ISO Inferred from Sequence Orthology more info
enables ferroxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ferroxidase activity	TAS Traceable Author Statement more info	PubMed
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular iron ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aconitate hydratase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lyase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of succinate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of succinate dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ferritin, mitochondrial

Names: ferritin H; ferritin heavy chain 3

NP_080562.2

EC 1.16.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.