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    VN1R3 vomeronasal 1 receptor 3 [ Homo sapiens (human) ]

    Gene ID: 317702, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VN1R3provided by HGNC
    Official Full Name
    vomeronasal 1 receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:19867
    See related
    AllianceGenome:HGNC:19867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    V1RL3; FKSG46; V1RL3p
    Summary
    Predicted to enable pheromone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; response to pheromone; and sensory perception of chemical stimulus. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Orthologs
    all
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    Genomic context

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    See VN1R3 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31807585..31808853, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (32194951..32196219, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31818906..31820174, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 67 pseudogene Neighboring gene protein phosphatase 2 catalytic subunit beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:31854092-31855001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7427 Neighboring gene RNA binding motif protein 22 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 3948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7429 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:31888713-31889912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31891365-31891865 Neighboring gene zinc finger protein 267 Neighboring gene PTPRF interacting protein alpha 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs. Young JM, et al. Genome Res, 2005 Feb. PMID 15653832, Free PMC Article
    2. Novel human vomeronasal receptor-like genes reveal species-specific families. Rodriguez I, et al. Curr Biol, 2002 Jun 25. PMID 12123587
    3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. Zhang J, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12826614, Free PMC Article
    4. Extreme variability among mammalian V1R gene families. Young JM, et al. Genome Res, 2010 Jan. PMID 19952141, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129709, MGC129710

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables pheromone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal type-1 receptor 3
    Names
    V1R-like 3
    V1RL3 pseudogene
    V1r-like receptor 3
    vomeronasal 1 receptor 3 pseudogene
    vomeronasal 1 receptor 4 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174980.2 → NP_778145.2  vomeronasal type-1 receptor 3

      Status: VALIDATED

      Description
      Transcript Variant: This transcript represents the functional allele encoding the full-length protein.
      Source sequence(s)
      AF336873, BC107074
      UniProtKB/Swiss-Prot
      Q9BXE9
      Conserved Domains (1) summary
      cd13949
      Location:8 → 300
      7tm_V1R_pheromone; vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. NR_171047.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) contains an indel in the CDS relative to the genome that creates a protein with shorter, unsupported N-terminus compared to variant 1.
      Source sequence(s)
      AC002519

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      31807585..31808853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      32194951..32196219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005664.3: Suppressed sequence

      Description
      NG_005664.3: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXE9.1 GenPept UniProtKB/Swiss-Prot:Q9BXE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials