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    Vangl1 VANGL planar cell polarity 1 [ Mus musculus (house mouse) ]

    Gene ID: 229658, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Vangl1provided by MGI
    Official Full Name
    VANGL planar cell polarity 1provided by MGI
    Primary source
    MGI:MGI:2159344
    See related
    Ensembl:ENSMUSG00000027860 AllianceGenome:MGI:2159344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lpp2; Stb2; Stbm; Kitenin
    Summary
    Acts upstream of or within mucociliary clearance and pigmentation. Located in lateral plasma membrane. Is expressed in several structures, including central nervous system; future brain; notochord; sensory organ; and skin. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Orthologous to human VANGL1 (VANGL planar cell polarity protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 5.6), liver E14 (RPKM 5.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vangl1 in Genome Data Viewer
    Location:
    3 F2.2; 3 44.3 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102060899..102112012, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102153583..102204744, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08557 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08558 Neighboring gene calsequestrin 2 Neighboring gene STARR-seq mESC enhancer starr_08562 Neighboring gene STARR-seq mESC enhancer starr_08563 Neighboring gene STARR-seq mESC enhancer starr_08564 Neighboring gene predicted gene 16160 Neighboring gene RIKEN cDNA A230001M10 gene Neighboring gene STARR-seq mESC enhancer starr_08569 Neighboring gene STARR-seq mESC enhancer starr_08571 Neighboring gene predicted gene, 40110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A peptide interfering with the dimerization of oncogenic KITENIN protein and its stability suppresses colorectal tumour progression. Kim SJ, et al. Clin Transl Med, 2022 Jul. PMID 35853101, Free PMC Article
    2. The homologous genes Vangl1 and Vangl2 are required for embryo implantation in the uterus of mice during early pregnancy. Zhang H, et al. Gene, 2015 Jan 25. PMID 25445275
    3. Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein. Lee JH, et al. Cancer Res, 2005 Oct 1. PMID 16204073
    4. Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma. Bui KC, et al. Exp Cell Res, 2018 Mar 1. PMID 29366806
    5. Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes. Belotti E, et al. PLoS One, 2012. PMID 23029439, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.
      Title: Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.
    2. Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.
      Title: Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.
    3. A peptide interfering with the dimerization of oncogenic KITENIN protein and its stability suppresses colorectal tumour progression.
      Title: A peptide interfering with the dimerization of oncogenic KITENIN protein and its stability suppresses colorectal tumour progression.
    4. Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease.
      Title: Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease.
    5. High KITENIN expression is associated with cholangiocarcinoma.
      Title: Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma.
    6. In Pax2-Cre; V1V2 Conditional knockout mice, the loss of both VANGL proteins significantly disrupts planar polarity throughout the utricular maculae
      Title: Domineering non-autonomy in Vangl1;Vangl2 double mutants demonstrates intercellular PCP signaling in the vertebrate inner ear.
    7. Exogenously introduced expression of green fluorescent protein (GFP)-tagged core PCP factors by electroporation revealed that Vangl1, Vangl2 and Prickle2 are localized on the ovarian side of the cell periphery in the oviduct.Our data collectively suggest that the mechanism for maintenance of Vangl2 asymmetry in mature mouse oviduct is different from the microtubule dependent polarized transport model
      Title: Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium.
    8. Elevated coexpression of KITENIN and ErbB4-CYT-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment
      Title: Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss.
    9. Findings identify that KITENIN-targeting miR-124, miR-27a, and miR-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR-124 plays a suppressor role in colorectal tumorigenesis.
      Title: KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis.
    10. Vangl1 and Vangl2 may play a key role in the embryo implantation of mice
      Title: The homologous genes Vangl1 and Vangl2 are required for embryo implantation in the uterus of mice during early pregnancy.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mucociliary clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vang-like protein 1
    Names
    KAI1 COOH-terminal interacting tetraspanin
    loop-tail protein 2
    strabismus
    van Gogh-like protein 1
    vang, van gogh-like 1
    vang-like 1 (van gogh, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177545.5 → NP_808213.2  vang-like protein 1

      See identical proteins and their annotated locations for NP_808213.2

      Status: VALIDATED

      Source sequence(s)
      AC159255, AF481860, BY729182
      Consensus CDS
      CCDS17686.1
      UniProtKB/Swiss-Prot
      B2RRP5, Q80Z96, Q8QZT3
      UniProtKB/TrEMBL
      Q3UXU7
      Related
      ENSMUSP00000029453.8, ENSMUST00000029453.13
      Conserved Domains (1) summary
      pfam06638
      Location:26 → 526
      Strabismus; Strabismus protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      102060899..102112012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501395.5 → XP_006501458.1  vang-like protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3UXU7
      Conserved Domains (1) summary
      pfam06638
      Location:25 → 539
      Strabismus; Strabismus protein

    RNA

    1. XR_004941312.1 RNA Sequence

    2. XR_004941311.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001165951.2: Suppressed sequence

      Description
      NM_001165951.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Z96.2 GenPept UniProtKB/Swiss-Prot:Q80Z96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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