Slco1b2 solute carrier organic anion transporter family, member 1b2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco1b2provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 1b2provided by MGI
Primary source: MGI:MGI:1351899
See related: Ensembl:ENSMUSG00000030236 AllianceGenome:MGI:1351899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OATP2; Oatp4; lst-1; OATP-C; mlst-1; Oatp1b2; Slc21a6; Slc21a10; 7330442B20Rik
Summary: Predicted to enable oligopeptide transmembrane transporter activity; organic anion transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport; oligopeptide transport; and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder and gastrointestinal stromal tumor. Orthologous to human SLCO1B1 (solute carrier organic anion transporter family member 1B1); SLCO1B3 (solute carrier organic anion transporter family member 1B3); and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 49.6), liver E18 (RPKM 18.8) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 G2; 6 72.57 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (141575178..141632372)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (141629452..141686646)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.
Title: Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.
This finding is consistent with the metabolism of regorafenib occurring via two competing pathways, and the lack of Oatp1b2 results in decreased clearance of Regorafenib.
Title: Interaction Between Sex and Organic Anion-Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice.
Experiments testing the cellular uptake of androgens suggest that testosterone is an excellent substrate of OATP1B3 and cells expressing a doxycycline-inducible SLCO1B3 construct had greater uptake of a clinically relevant concentration of 3H-testosterone . When compared with Slco1b2 (-/-) mice, Slco1b2 (-/-)/hSLCO1B3 knockins had greater greater hepatic uptakeand lower plasma exposure to 3H-testosterone
Title: Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.
important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported.
Title: Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Protection against phalloidin hepatotoxicity by oleanolic acid involves activation of Nrf2 and suppression of Oatp1b2.
Title: Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.
the combination of NASH-associated decrease in compensatory Oatp transporters and Oatp1b2 genetic loss caused a synergistic increase in pravastatin plasma and tissue concentrations in kidney and muscle
Title: Synergistic interaction between genetics and disease on pravastatin disposition.
Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Title: OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
These findings showed that deficiency of Oatp1b transporters alters the absorption, distribution, and elimination of hydroxyurea.
Title: Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.
Oatp1c1 deficiency has an effect on thyroid hormone metabolism and action in the mouse brain
Title: Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.
This study indicates that Oatp1b2 has a major role in the hepatic uptake of unconjugated bile acids.
Title: Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

General gene information

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Markers

D6Mit112 (e-PCR), detects polymorphism
- UniSTS:130655

Slco1b2 (e-PCR), detects polymorphism
- UniSTS:546034

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oligopeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oligopeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IEA Inferred from Electronic Annotation more info
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transport	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1B2

Names: liver-specific organic anion transporter 1; solute carrier family 21 (organic anion transporter), member 10; solute carrier family 21 (organic anion transporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020495.2 → NP_065241.1 solute carrier organic anion transporter family member 1B2

See identical proteins and their annotated locations for NP_065241.1

Status: VALIDATED

Source sequence(s)

AC155326

Consensus CDS

CCDS20678.1

UniProtKB/Swiss-Prot

Q9JI79, Q9JJJ1, Q9JJL3

UniProtKB/TrEMBL

A0A0N4SUN2

Related

ENSMUSP00000044326.7, ENSMUST00000042812.9

Conserved Domains (1) summary

cl28910
Location:26 → 557

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

141575178..141632372

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506963.2 → XP_006507026.1 solute carrier organic anion transporter family member 1B2 isoform X1

See identical proteins and their annotated locations for XP_006507026.1

UniProtKB/Swiss-Prot

Q9JI79, Q9JJJ1, Q9JJL3

UniProtKB/TrEMBL

A0A0N4SUN2

Conserved Domains (1) summary

cl28910
Location:26 → 557

MFS; Major Facilitator Superfamily
XM_017321611.3 → XP_017177100.1 solute carrier organic anion transporter family member 1B2 isoform X1

UniProtKB/Swiss-Prot

Q9JI79, Q9JJJ1, Q9JJL3

UniProtKB/TrEMBL

A0A0N4SUN2

Related

ENSMUSP00000144747.2, ENSMUST00000203597.2

Conserved Domains (1) summary

cl28910
Location:26 → 557

MFS; Major Facilitator Superfamily
XM_036166208.1 → XP_036022101.1 solute carrier organic anion transporter family member 1B2 isoform X1

UniProtKB/Swiss-Prot

Q9JI79, Q9JJJ1, Q9JJL3

UniProtKB/TrEMBL

A0A0N4SUN2

Conserved Domains (1) summary

cl28910
Location:26 → 557

MFS; Major Facilitator Superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178235.2: Suppressed sequence

Description

NM_178235.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.