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ST2 suppression of tumorigenicity 2 [ Homo sapiens (human) ]

Gene ID: 6761, updated on 31-Aug-2024

Summary

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Official Symbol
ST2provided by HGNC
Official Full Name
suppression of tumorigenicity 2provided by HGNC
Primary source
MIM:185440
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information
Note: This region (ST2; GeneID: 6761) on chromosome 11 represents a putative locus that is associated with various forms of cancer. It has been confused in the published literature with the IL1RL1 gene (GeneID: 9173), which has the alias ST2, on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. [23 Jun 2016]

Genomic context

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Location:
11p14.3-p12

Bibliography

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Related articles in PubMed

  1. Increased soluble ST2 and IL‑4 serum levels are associated with disease severity in patients with membranous nephropathy. Zhang Z, et al. Mol Med Rep, 2018 Feb. PMID 29207152
  2. Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage. Lissak IA, et al. Stroke, 2020 Apr. PMID 32156203, Free PMC Article
  3. ST2 as a predictor of late ventricular remodeling after myocardial infarction. Bière L, et al. Int J Cardiol, 2018 May 15. PMID 29486997
  4. Soluble ST2: A complex and diverse role in several diseases. Homsak E, et al. Clin Chim Acta, 2020 Aug. PMID 32305537
  5. Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants. Griffiths M, et al. J Perinatol, 2020 Nov. PMID 32366869, Free PMC Article

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of Neuroinflammation: Advances in Roles and Mechanisms of the IL-33/ST2 Axis Involved in Ischemic Stroke.
    Title: Modulation of Neuroinflammation: Advances in Roles and Mechanisms of the IL-33/ST2 Axis Involved in Ischemic Stroke.
  2. Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19.
    Title: Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19.
  3. Exploring the significance of interleukin-33/ST2 axis in minimal change disease.
    Title: Exploring the significance of interleukin-33/ST2 axis in minimal change disease.
  4. Galectin-3 and suppression of tumorigenicity 2: Two emerging cardiac biomarkers that may be predictors of cardiac fibrosis development in sport.
    Title: Galectin-3 and suppression of tumorigenicity 2: Two emerging cardiac biomarkers that may be predictors of cardiac fibrosis development in sport.
  5. The association of serum IL-33/ST2 expression with hepatocellular carcinoma.
    Title: The association of serum IL-33/ST2 expression with hepatocellular carcinoma.
  6. Interleukin-33 and Soluble ST2 Levels in Infants with Hypoxic-Ischemic Encephalopathy.
    Title: Interleukin-33 and Soluble ST2 Levels in Infants with Hypoxic-Ischemic Encephalopathy.
  7. IL-33/ST2 axis of human amnion fibroblasts participates in inflammatory reactions at parturition.
    Title: IL-33/ST2 axis of human amnion fibroblasts participates in inflammatory reactions at parturition.
  8. Interleukin-33 and soluble suppression of tumorigenicity 2 in scleroderma cardiac involvement.
    Title: Interleukin-33 and soluble suppression of tumorigenicity 2 in scleroderma cardiac involvement.
  9. Differential Expression of Caveolin-3, Suppression of Tumorigenicity 2, and Growth Differentiation Factor-15 Genes and Their Association with Acute Myocardial Infarction: A Cross-Sectional Study in a Multi-Specialty Hospital in Tamil Nadu.
    Title: Differential Expression of Caveolin-3, Suppression of Tumorigenicity 2, and Growth Differentiation Factor-15 Genes and Their Association with Acute Myocardial Infarction: A Cross-Sectional Study in a Multi-Specialty Hospital in Tamil Nadu.
  10. The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
    Title: The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (144)

Phenotypes

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Associated conditions

Description Tests
suppression of tumorigenicity 2
OMIM: 185440GeneReviews: Not available

General gene information

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Property

  • phenotype only

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