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TRPV2 transient receptor potential cation channel subfamily V member 2 [ Homo sapiens (human) ]

Gene ID: 51393, updated on 29-Oct-2024

Summary

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Official Symbol
TRPV2provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 2provided by HGNC
Primary source
HGNC:HGNC:18082
See related
Ensembl:ENSG00000187688 MIM:606676; AllianceGenome:HGNC:18082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VRL; VRL1; VRL-1
Summary
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRPV2 in Genome Data Viewer
Location:
17p11.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16415571..16437003)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16317872..16339304)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16318885..16340317)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.878 Neighboring gene ferritin light chain pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11758 Neighboring gene uncharacterized LOC124904150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16329088-16329588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16339567-16340199 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16340803-16341704 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16341705-16342604 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16342605-16343506 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A Neighboring gene small nucleolar RNA host gene 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis. Lévêque M, et al. Sci Rep, 2018 Mar 9. PMID 29523858, Free PMC Article
  2. The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer. Marinelli O, et al. Int J Mol Sci, 2020 Jul 29. PMID 32751388, Free PMC Article
  3. Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. Liu G, et al. Cancer Genet Cytogenet, 2010 Feb. PMID 20113837
  4. Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. Mercado J, et al. J Neurosci, 2010 Oct 6. PMID 20926660, Free PMC Article
  5. The expression and role of TRPV2 in esophageal squamous cell carcinoma. Kudou M, et al. Sci Rep, 2019 Nov 5. PMID 31690728, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.
    Title: Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.
  2. TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity.
    Title: TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity.
  3. TCAF1 promotes TRPV2-mediated Ca[2+] release in response to cytosolic DNA to protect stressed replication forks.
    Title: TCAF1 promotes TRPV2-mediated Ca(2+) release in response to cytosolic DNA to protect stressed replication forks.
  4. TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells.
    Title: TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells.
  5. Ion channel TRPV2 is critical in enhancing B cell activation and function.
    Title: Ion channel TRPV2 is critical in enhancing B cell activation and function.
  6. Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer.
    Title: Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer.
  7. TRPV2, a novel player in the human ovary and human granulosa cells.
    Title: TRPV2, a novel player in the human ovary and human granulosa cells.
  8. The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.
    Title: The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.
  9. Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway.
    Title: Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway.
  10. Impact of the TRPV2 Inhibitor on Advanced Heart Failure in Patients with Muscular Dystrophy: Exploratory Study of Biomarkers Related to the Efficacy of Tranilast.
    Title: Impact of the TRPV2 Inhibitor on Advanced Heart Failure in Patients with Muscular Dystrophy: Exploratory Study of Biomarkers Related to the Efficacy of Tranilast.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transient receptor potential cation channel V, member 2 (TRPV2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity TAS
Traceable Author Statement
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables monoatomic ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within response to temperature stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in cell body IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone membrane IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily V member 2
Names
OTRPC2
osm-9-like TRP channel 2
vanilloid receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016113.5 → NP_057197.2  transient receptor potential cation channel subfamily V member 2

    See identical proteins and their annotated locations for NP_057197.2

    Status: REVIEWED

    Source sequence(s)
    AK289705, BC018926
    Consensus CDS
    CCDS32576.1
    UniProtKB/Swiss-Prot
    A6NML2, A8K0Z0, Q9Y5S1, Q9Y670
    Related
    ENSP00000342222.7, ENST00000338560.12
    Conserved Domains (3) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 764
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    16415571..16437003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721541.5 → XP_006721604.1  transient receptor potential cation channel subfamily V member 2 isoform X2

    Conserved Domains (3) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 732
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  2. XM_011523922.3 → XP_011522224.1  transient receptor potential cation channel subfamily V member 2 isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 705
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  3. XM_006721543.5 → XP_006721606.1  transient receptor potential cation channel subfamily V member 2 isoform X5

    See identical proteins and their annotated locations for XP_006721606.1

    Conserved Domains (5) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:452 → 652
    Ion_trans; Ion transport protein
    pfam12796
    Location:114 → 192
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:163 → 229
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  4. XM_047436217.1 → XP_047292173.1  transient receptor potential cation channel subfamily V member 2 isoform X5

  5. XM_005256677.3 → XP_005256734.1  transient receptor potential cation channel subfamily V member 2 isoform X7

    See identical proteins and their annotated locations for XP_005256734.1

    Conserved Domains (3) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 630
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  6. XM_017024732.3 → XP_016880221.1  transient receptor potential cation channel subfamily V member 2 isoform X9

  7. XM_005256676.3 → XP_005256733.1  transient receptor potential cation channel subfamily V member 2 isoform X1

    See identical proteins and their annotated locations for XP_005256733.1

    Conserved Domains (3) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 763
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  8. XM_047436216.1 → XP_047292172.1  transient receptor potential cation channel subfamily V member 2 isoform X4

  9. XM_017024730.3 → XP_016880219.1  transient receptor potential cation channel subfamily V member 2 isoform X6

  10. XM_017024731.3 → XP_016880220.1  transient receptor potential cation channel subfamily V member 2 isoform X8

  11. XM_011523923.3 → XP_011522225.1  transient receptor potential cation channel subfamily V member 2 isoform X12

    Conserved Domains (4) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:114 → 192
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:163 → 229
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  12. XM_047436219.1 → XP_047292175.1  transient receptor potential cation channel subfamily V member 2 isoform X11

  13. XM_005256678.6 → XP_005256735.1  transient receptor potential cation channel subfamily V member 2 isoform X10

    Conserved Domains (4) summary
    cd00204
    Location:163 → 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:114 → 192
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:163 → 229
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:162 → 193
    ANK; ANK repeat [structural motif]

  14. XM_047436220.1 → XP_047292176.1  transient receptor potential cation channel subfamily V member 2 isoform X13

  15. XM_011523925.3 → XP_011522227.1  transient receptor potential cation channel subfamily V member 2 isoform X14

    UniProtKB/TrEMBL
    B3KMH7
    Conserved Domains (1) summary
    pfam00520
    Location:22 → 222
    Ion_trans; Ion transport protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    16317872..16339304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316379.1 → XP_054172354.1  transient receptor potential cation channel subfamily V member 2 isoform X2

  2. XM_054316380.1 → XP_054172355.1  transient receptor potential cation channel subfamily V member 2 isoform X3

  3. XM_054316383.1 → XP_054172358.1  transient receptor potential cation channel subfamily V member 2 isoform X5

  4. XM_054316382.1 → XP_054172357.1  transient receptor potential cation channel subfamily V member 2 isoform X5

  5. XM_054316385.1 → XP_054172360.1  transient receptor potential cation channel subfamily V member 2 isoform X7

  6. XM_054316387.1 → XP_054172362.1  transient receptor potential cation channel subfamily V member 2 isoform X9

  7. XM_054316378.1 → XP_054172353.1  transient receptor potential cation channel subfamily V member 2 isoform X1

  8. XM_054316381.1 → XP_054172356.1  transient receptor potential cation channel subfamily V member 2 isoform X4

  9. XM_054316384.1 → XP_054172359.1  transient receptor potential cation channel subfamily V member 2 isoform X6

  10. XM_054316386.1 → XP_054172361.1  transient receptor potential cation channel subfamily V member 2 isoform X8

  11. XM_054316390.1 → XP_054172365.1  transient receptor potential cation channel subfamily V member 2 isoform X12

  12. XM_054316389.1 → XP_054172364.1  transient receptor potential cation channel subfamily V member 2 isoform X11

  13. XM_054316388.1 → XP_054172363.1  transient receptor potential cation channel subfamily V member 2 isoform X10

  14. XM_054316391.1 → XP_054172366.1  transient receptor potential cation channel subfamily V member 2 isoform X13

  15. XM_054316392.1 → XP_054172367.1  transient receptor potential cation channel subfamily V member 2 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5S1.1 GenPept UniProtKB/Swiss-Prot:Q9Y5S1

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