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Marf1 Meiosis regulator and mRNA stability factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49895, updated on 18-Sep-2024

Summary

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Official Symbol
Marf1provided by FlyBase
Official Full Name
Meiosis regulator and mRNA stability factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0039972
Locus tag
Dmel_CG17018
See related
AllianceGenome:FB:FBgn0039972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE40762; CG17018; CG17410; Dmel\CG17018; LKAP; MARF1
Summary
Enables CCR4-NOT complex binding activity and mRNA binding activity involved in posttranscriptional gene silencing. Involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening and posttranscriptional gene silencing. Located in cytoplasm and nucleus. Is expressed in organism. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Marf1 in Genome Data Viewer
Location:
40F7-40F7; 2-54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22308755..22368796)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22308755..22368796)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Tif-IA Neighboring gene Ribosomal protein L21 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR46268 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuroprotective potential of flavonoid rich Ascophyllum nodosum (FRAN) fraction from the brown seaweed on an Aβ(42) induced Alzheimer's model of Drosophila. Chauhan BS, et al. Phytomedicine, 2022 Jan. PMID 34906893
  2. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article
  3. The developmental proteome of Drosophila melanogaster. Casas-Vila N, et al. Genome Res, 2017 Jul. PMID 28381612, Free PMC Article
  4. The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation. Peng Y, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35699205, Free PMC Article
  5. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Li S, et al. Cell Rep, 2020 Aug 4. PMID 32755582, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dMarf1 translationally represses nos by binding to its mRNA.
    Title: Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 22311178-22311665 mobile_element_type = transposon:INE-1{}2128
  • Loc: 22314315-22314808 mobile_element_type = transposon:gypsy4{}2661
  • Loc: 22314971-22315275 mobile_element_type = transposon:INE-1{}2130
  • Loc: 22315673-22318155 mobile_element_type = transposon:frogger{}558
  • Loc: 22321993-22322176 mobile_element_type = transposon:INE-1{}2132
  • Loc: 22322856-22323070 mobile_element_type = transposon:gypsy6{}559
  • Loc: 22325984-22326373 mobile_element_type = transposon:INE-1{}2133
  • Loc: 22327585-22327681 mobile_element_type = transposon:Cr1a{}2556
  • Loc: 22329230-22337869 mobile_element_type = transposon:invader5{}1644
  • Loc: 22341330-22341383 mobile_element_type = transposon:diver2{}2646
  • Loc: 22342755-22342967 mobile_element_type = transposon:G4{}570
  • Loc: 22342974-22343153 mobile_element_type = transposon:Doc3{}Marf1[571]
  • Loc: 22346693-22348202 mobile_element_type = transposon:X{}572
  • Loc: 22352231-22352486 mobile_element_type = transposon:INE-1{}2149
  • Loc: 22353277-22353852 mobile_element_type = transposon:Cr1a{}2559
  • Loc: 22355883-22356416 mobile_element_type = transposon:Idefix{}2603

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CCR4-NOT complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CCR4-NOT complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-RNA adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
meiosis regulator and mRNA stability factor 1
Names
CG17018-PA
CG17018-PC
CG17018-PD
CG17018-PE
CG17018-PF
Marf1-PA
Marf1-PC
Marf1-PD
Marf1-PE
Marf1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22308755..22368796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259203.2 → NP_001246132.1  meiosis regulator and mRNA stability factor 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246132.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W5Y4
    Conserved Domains (3) summary
    cd08824
    Location:772 → 839
    LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
    cl14879
    Location:527 → 598
    LabA_like_C; C-terminal domain of LabA_like proteins
    cl17169
    Location:220 → 304
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_165414.2 → NP_724393.2  meiosis regulator and mRNA stability factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724393.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KWH0
    Related
    FBpp0085310
    Conserved Domains (3) summary
    cd08824
    Location:794 → 861
    LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
    cl14879
    Location:549 → 620
    LabA_like_C; C-terminal domain of LabA_like proteins
    cl17169
    Location:242 → 326
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_165415.2 → NP_724394.2  meiosis regulator and mRNA stability factor 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724394.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KWG9
    Related
    FBpp0085311
    Conserved Domains (3) summary
    cd08824
    Location:805 → 872
    LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
    cl14879
    Location:560 → 631
    LabA_like_C; C-terminal domain of LabA_like proteins
    cl17169
    Location:253 → 337
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_165413.2 → NP_724392.1  meiosis regulator and mRNA stability factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724392.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W5Y4
    Related
    FBpp0085309
    Conserved Domains (3) summary
    cd08824
    Location:772 → 839
    LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
    cl14879
    Location:527 → 598
    LabA_like_C; C-terminal domain of LabA_like proteins
    cl17169
    Location:220 → 304
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001259204.1 → NP_001246133.1  meiosis regulator and mRNA stability factor 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KWG9
    Conserved Domains (3) summary
    cd08824
    Location:805 → 872
    LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
    cl14879
    Location:560 → 631
    LabA_like_C; C-terminal domain of LabA_like proteins
    cl17169
    Location:253 → 337
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KWG9 Q7KWG9
Q7KWH0 Q7KWH0
Q8SXS3 Q8SXS3
Q9W5Y4 Q9W5Y4

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