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DIP2 DISCO Interacting Protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 252479, updated on 18-Sep-2024

Summary

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Official Symbol
DIP2provided by FlyBase
Official Full Name
DISCO Interacting Protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0024806
Locus tag
Dmel_CG7020
See related
AllianceGenome:FB:FBgn0024806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7020; Ddip2; Dmel\CG7020
Summary
Involved in axon guidance. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic brain; larval ventral nerve cord; spermatozoon; and visceral mesoderm. Orthologous to several human genes including DIP2B (disco interacting protein 2 homolog B) and DIP2C (disco interacting protein 2 homolog C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See DIP2 in Genome Data Viewer
Location:
61B3-61B3; 3-1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (250229..257954, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (250229..257954, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Enhancer of bithorax Neighboring gene methuselah-like 14 Neighboring gene ncRNA Neighboring gene Tudor staphylococcal nuclease Neighboring gene wee Augmin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes. Mondal S, et al. Elife, 2022 Jun 29. PMID 35766356, Free PMC Article
  2. Identification of glaikit in a genome-wide expression profiling for axonal bifurcation of the mushroom body in Drosophila. Nitta Y, et al. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28465232
  3. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons. Nitta Y, et al. Dev Biol, 2017 Jan 15. PMID 27908785
  4. DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body. Nitta Y, et al. Biochem Biophys Res Commun, 2017 May 20. PMID 28396149
  5. Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog. Mukhopadhyay M, et al. Gene, 2002 Jun 26. PMID 12137943

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here we show that DISCO interacting protein 2 (DIP2) is required for the accurate direction of axonal guidance.
    Title: DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body.
  2. These results reveal a function of DIP2 in the developing nervous system and provide a potential functional relationship between fatty acid metabolism and axon morphogenesis.
    Title: DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DISCO interacting protein 2
Names
CG7020-PA
CG7020-PB
CG7020-PC
CG7020-PD
CG7020-PE
DIP2-PA
DIP2-PB
DIP2-PC
DIP2-PD
DIP2-PE
NP_001246530.1
NP_001261191.1
NP_001261192.1
NP_001261193.1
NP_612019.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    250229..257954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259601.2 → NP_001246530.1  DISCO interacting protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246530.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDW1
    Conserved Domains (6) summary
    cd05905
    Location:469 → 1053
    Dip2; Disco-interacting protein 2 (Dip2)
    COG5068
    Location:33 → 368
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    PRK09192
    Location:469 → 1060
    PRK09192; acyl-CoA synthetase; Validated
    pfam00501
    Location:1124 → 1569
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:3 → 115
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:1141 → 1744
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001274263.1 → NP_001261192.1  DISCO interacting protein 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261192.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBG6
    Conserved Domains (6) summary
    cd05905
    Location:469 → 1053
    Dip2; Disco-interacting protein 2 (Dip2)
    COG5068
    Location:33 → 368
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    PRK09192
    Location:469 → 1060
    PRK09192; acyl-CoA synthetase; Validated
    pfam00501
    Location:1141 → 1586
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:3 → 115
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:1158 → 1761
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. NM_001274262.1 → NP_001261191.1  DISCO interacting protein 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261191.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGJ0
    Conserved Domains (6) summary
    cd05905
    Location:470 → 1054
    Dip2; Disco-interacting protein 2 (Dip2)
    COG5068
    Location:33 → 369
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    PRK09192
    Location:470 → 1061
    PRK09192; acyl-CoA synthetase; Validated
    pfam00501
    Location:1125 → 1570
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:3 → 115
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:1142 → 1745
    AFD_class_I; Adenylate forming domain, Class I superfamily

  4. NM_001274264.1 → NP_001261193.1  DISCO interacting protein 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261193.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDH5
    Conserved Domains (6) summary
    cd05905
    Location:470 → 1054
    Dip2; Disco-interacting protein 2 (Dip2)
    COG5068
    Location:33 → 369
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    PRK09192
    Location:470 → 1061
    PRK09192; acyl-CoA synthetase; Validated
    pfam00501
    Location:1142 → 1581
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:3 → 115
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:1159 → 1756
    AFD_class_I; Adenylate forming domain, Class I superfamily

  5. NM_138175.4 → NP_612019.2  DISCO interacting protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612019.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NGP2, Q9W0S9
    Related
    FBpp0072420
    Conserved Domains (6) summary
    cd05905
    Location:470 → 1054
    Dip2; Disco-interacting protein 2 (Dip2)
    COG5068
    Location:33 → 369
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    PRK09192
    Location:470 → 1061
    PRK09192; acyl-CoA synthetase; Validated
    pfam00501
    Location:1142 → 1587
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:3 → 115
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:1159 → 1762
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDW1 M9NDW1
M9PBG6 M9PBG6
M9PDH5 M9PDH5
M9PGJ0 M9PGJ0
Q8MRM9 Q8MRM9
Q9W0S9.2 Q9W0S9

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